microRNASeq

Gene ID	Transcript ID	Common Gene Name	# of miRNA targets for specified miRNAs	Chromosome	Strand Direction	Transcript Link to view miRNA target predictions	Gene Link	Description
AC8.11	AC8.11	AC8.11	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
AC8.4	AC8.4	AC8.4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0198.1	B0198.1	tsp-20	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0198.3	B0198.3a	B0198.3	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0272.1	B0272.1	tbb-4	3	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0294.1	B0294.1	B0294.1	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0302.2	B0302.2	B0302.2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0310.1	B0310.1b	B0310.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	B0310.1 encodes a nematode-specific transmembrane protein. loss of B0310.1 activity via RNAi results in reduced fat content in wild-type and tub-1 mutant animals, suggesting that B0301.1 plays a role in lipid metabolism. [Source: WormBase]
B0310.5	B0310.5	ugt-46	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0310.6	B0310.6	B0310.6	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0395.1	B0395.1	nhx-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	nhx-1 encodes a sodium/proton exchanger expressed intracellularly within hypodermal and muscle cells. NHX-1 is required for embryonic viability, and is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton. [Source: WormBase]
B0395.3	B0395.3.1	B0395.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	B0395.3 is orthologous to the human gene CHOLINE ACETYLTRANSFERASE ISOFORM R (CHAT. OMIM:118490), which when mutated leads to disease. [Source: WormBase]
B0403.3	B0403.3	B0403.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0410.2	B0410.2a	vang-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase]
B0410.2	B0410.2b	vang-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase]
B0416.1	B0416.1	B0416.1	5	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0416.5	B0416.5a	B0416.5	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0416.6	B0416.6	gly-13	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates. gly-13 is expressed throughout development in many cell types. gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14. [Source: WormBase]
B0563.4	B0563.4.1	tmbi-4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.4	B0563.4.2	tmbi-4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6a	B0563.6	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6b.1	B0563.6	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6b.2	B0563.6	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6c	B0563.6	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C01C10.1	C01C10.1	clc-2	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia. claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes. clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein. [Source: WormBase]
C01C10.3	C01C10.3.1	acl-12	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C01C10.3	C01C10.3.2	acl-12	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C01C10.4	C01C10.4	clc-5	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	clc-5 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia. CLC-5 is worm-specific, with obvious homologs only in C. elegans. CLC-5 has no obvious function in mass RNAi assays. claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. [Source: WormBase]
C01C4.1	C01C4.1	nlp-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	nlp-1 encodes a predicted neuropeptide-like protein of the MSFamide family with similarity to Aplysia californica (sea hare) buccalin, a neuropeptide that regulates acetylcholine-induced muscle contraction. NLP-1 is expressed in the phasmid PHB tail sensory neuron, lateral neurons, head neurons, and the intestine. the precise role of NLP-1 in nervous system function and development is not yet known. [Source: WormBase]
C01C4.3	C01C4.3b	C01C4.3	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	C01C4.3 encodes a serine/threonine protein kinase. [Source: WormBase]
C02B4.1	C02B4.1	adt-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis. [Source: WormBase]
C02B4.4	C02B4.4	C02B4.4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02B8.2	C02B8.2	fbxc-38	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C02B8.3	C02B8.3	C02B8.3	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C02B8.5	C02B8.5	C02B8.5	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	C02B8.5 encodes a homolog of the functionally active Fmrf Receptor (FR. CG2114) of D. melanogaster. it is thus possible that C02B8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). [Source: WormBase]
C02B8.6	C02B8.6	C02B8.6	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02C6.2	C02C6.2a	olrn-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	olrn-1 encodes, by alternative splicing, two isoforms of a transmembrane protein required for differentiation of the AWC[ON] neuron, expression of str-2 in AWC[ON], adaptation to benzaldehyde, chemotaxis to butanone, and enhancement of chemotaxis to butanone by the presence of food. OLRN-1 is orthologous to Drosophila melanogaster RAW and Schistosoma japonicum SJCHGC05616. while OLRN-1 has orthologs in nematodes, trematodes, and arthropods, its has no obvious chordate homologs. OLRN-6 is expressed in many pharyngeal neurons and some head neurons, but is required solely in the AWC[ON] neuron for butanone enhancement. OLRN-6's function in butanone enhancement is both serotonin- and dopamine-independent, and appears to also act in chemotactic enhancement of 2,3-pentanedione and isoamyl alcohol. by orthology with RAW, OLRN-6 is predicted to inhibit JNK-1 signalling, which may in turn allow the asymmetrical AWC[ON] fate to emerge. [Source: WormBase]
C02C6.2	C02C6.2b	olrn-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	olrn-1 encodes, by alternative splicing, two isoforms of a transmembrane protein required for differentiation of the AWC[ON] neuron, expression of str-2 in AWC[ON], adaptation to benzaldehyde, chemotaxis to butanone, and enhancement of chemotaxis to butanone by the presence of food. OLRN-1 is orthologous to Drosophila melanogaster RAW and Schistosoma japonicum SJCHGC05616. while OLRN-1 has orthologs in nematodes, trematodes, and arthropods, its has no obvious chordate homologs. OLRN-6 is expressed in many pharyngeal neurons and some head neurons, but is required solely in the AWC[ON] neuron for butanone enhancement. OLRN-6's function in butanone enhancement is both serotonin- and dopamine-independent, and appears to also act in chemotactic enhancement of 2,3-pentanedione and isoamyl alcohol. by orthology with RAW, OLRN-6 is predicted to inhibit JNK-1 signalling, which may in turn allow the asymmetrical AWC[ON] fate to emerge. [Source: WormBase]
C02D4.1	C02D4.1	jud-4	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	jud-4 encodes an unfamiliar protein, putatively secreted, that is required both for normal sensitivity to ethanol and for survival after freezing and thawing. JUD-4 is expressed in hypodermis and vulval muscles. JUD-4 is orthologous to Brugia malayi Bm1_40315, but lacks obvious orthologies to non-nematode proteins. JUD-4's C-terminal domain has possible similarity to F40E10.5, and to proteins such as human HOMER1. jud-4(ys18) mutants show delayed sensitivity to ethanol levels that rapidly paralyze normal worms, but do not survive freezing and rethawing as does wild-type. JUD-4 has no obvious function in mass RNAi assays. [Source: WormBase]
C02F12.1	C02F12.1b	tsp-17	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.3	C02F12.3.1	C02F12.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.3	C02F12.3.2	C02F12.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.3	C02F12.3.3	C02F12.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.9	C02F12.9	C02F12.9	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C02H7.2	C02H7.2	npr-19	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02H7.3	C02H7.3a	aex-3	5	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	aex-3 encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584). AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively. AEX-3 is also required for egg laying and locomotion. AEX-3 is expressed in nearly all neurons. [Source: WormBase]
C03A3.1	C03A3.1a	C03A3.1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03A3.1	C03A3.1b	C03A3.1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03A3.2	C03A3.2.1	C03A3.2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03B1.13	C03B1.13	C03B1.13	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C03B1.1	C03B1.1	C03B1.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03B1.5	C03B1.5	C03B1.5	4	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03B1.7	C03B1.7	C03B1.7	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03B1.9	C03B1.9	C03B1.9	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C03F11.1	C03F11.1	C03F11.1	3	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03F11.4	C03F11.4.1	C03F11.4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C03F11.4	C03F11.4.2	C03F11.4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C03F11.4	C03F11.4.3	C03F11.4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C03H12.1	C03H12.1	C03H12.1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04A11.1	C04A11.1	C04A11.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04A11.4	C04A11.4	adm-2	3	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family). like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. [Source: WormBase]
C04B4.1	C04B4.1.1	C04B4.1	3	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04B4.1	C04B4.1.2	C04B4.1	3	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04B4.4	C04B4.4	C04B4.4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04C11.2	C04C11.2.1	arrd-25	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04C11.2	C04C11.2.2	arrd-25	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04E7.3	C04E7.3	C04E7.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C04E7.4	C04E7.4	C04E7.4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C04F6.1	C04F6.1	vit-5	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	vit-5 encodes a vitellogenin, a lipid-binding protein precursor related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent. by homology, VIT-5 is predicted to function as a lipid transport protein. loss of vit-5 activity via large-scale RNA-mediated interference (RNAi) screens indicates that VIT-5 is required for embryogenesis and normal rates of postembryonic growth. VIT-5 is a major yolk component and is expressed exclusively in the adult hermaphrodite intestine from which it is secreted into the pseudocoelomic space and taken up by oocytes. [Source: WormBase]
C04F6.3	C04F6.3.1	cht-1	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	cht-1 encodes a chitinase orthologous to human chitinase-1 (OMIM:600031, mutations are associated with chitotriosidase deficiency). CHT-1 is predicted to function as an extracellular O-glycosyl hydrolase that hydrolyzes the glycosidic bond between two or more carbohydrates. in C. elegans, CHT-1 may play a role in embryogenesis, and may also be required for cuticle degradation during molting and degradation of chitin-containing pathogens as part of a host defense mechanism. [Source: WormBase]
C04F6.3	C04F6.3.2	cht-1	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	cht-1 encodes a chitinase orthologous to human chitinase-1 (OMIM:600031, mutations are associated with chitotriosidase deficiency). CHT-1 is predicted to function as an extracellular O-glycosyl hydrolase that hydrolyzes the glycosidic bond between two or more carbohydrates. in C. elegans, CHT-1 may play a role in embryogenesis, and may also be required for cuticle degradation during molting and degradation of chitin-containing pathogens as part of a host defense mechanism. [Source: WormBase]
C04F6.5	C04F6.5	dhs-27	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	dhs-27 encodes a short-chain dehydrogenase predicted to be mitochondrial. [Source: WormBase]
C04F6.7	C04F6.7	C04F6.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C05A9.1	C05A9.1a	pgp-5	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily. by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins. however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. [Source: WormBase]
C05A9.1	C05A9.1b	pgp-5	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily. by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins. however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. [Source: WormBase]
C05C9.1	C05C9.1	C05C9.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C05D9.1	C05D9.1.1	snx-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C05D9.1	C05D9.1.2	snx-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C05D9.1	C05D9.1.3	snx-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C05D9.2	C05D9.2.1	lmp-2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase]
C05D9.2	C05D9.2.2	lmp-2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase]
C05D9.2	C05D9.2.3	lmp-2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase]
C05D9.7	C05D9.7	C05D9.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C05E11.2	C05E11.2	C05E11.2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C05E11.4	C05E11.4	amt-1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	amt-1 encodes a transmembrane transporter that by homology, is predicted to transport ammonium ions across the plasma membrane. as loss of amt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of AMT-1 in C. elegans development and/or behavior is not yet known. [Source: WormBase]
C05G5.4	C05G5.4.1	C05G5.4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C05G5.4	C05G5.4.2	C05G5.4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C06E2.1	C06E2.1	C06E2.1	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C06G1.1	C06G1.1a	C06G1.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C06G1.1	C06G1.1b	C06G1.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C06G1.2	C06G1.2	C06G1.2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C06G1.4	C06G1.4.1	ain-1	3	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]
C06G1.4	C06G1.4.2	ain-1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]
C07A12.3	C07A12.3a	nhr-35	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C07A12.5	C07A12.5a	spr-3	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C07A12.7	C07A12.7a.1	C07A12.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C07A12.7	C07A12.7a.2	C07A12.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C07A12.7	C07A12.7b	C07A12.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C07A12.7	C07A12.7c.1	C07A12.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C07A4.1	C07A4.1	tiar-3	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl

Gene ID

Transcript ID

Common Gene Name

# of miRNA targets
for specified miRNAs

Chromosome

Strand Direction

Transcript Link to view miRNA target predictions

Gene Link

Description

AC8.11

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

AC8.4

23 X

Reverse

View as cDNA map |
View as Table

Internal |
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B0198.1

tsp-20

23 X

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B0198.3

B0198.3a

B0198.3

23 X

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B0272.1

tbb-4

23 X

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B0294.1

23 X

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B0302.2

23 X

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B0310.1

B0310.1b

B0310.1

23 X

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B0310.1 encodes a nematode-specific transmembrane protein. loss of B0310.1 activity via RNAi results in reduced fat content in wild-type and tub-1 mutant animals, suggesting that B0301.1 plays a role in lipid metabolism. [Source: WormBase]

B0310.5

ugt-46

23 X

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B0310.6

23 X

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B0395.1

nhx-1

23 X

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nhx-1 encodes a sodium/proton exchanger expressed intracellularly within hypodermal and muscle cells. NHX-1 is required for embryonic viability, and is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton. [Source: WormBase]

B0395.3

B0395.3.1

B0395.3

23 X

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B0395.3 is orthologous to the human gene CHOLINE ACETYLTRANSFERASE ISOFORM R (CHAT. OMIM:118490), which when mutated leads to disease. [Source: WormBase]

B0403.3

23 X

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B0410.2

B0410.2a

vang-1

23 X

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vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase]

B0410.2

B0410.2b

vang-1

23 X

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B0416.1

23 X

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B0416.5

B0416.5a

B0416.5

23 X

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B0416.6

gly-13

23 X

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gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates. gly-13 is expressed throughout development in many cell types. gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14. [Source: WormBase]

B0563.4

B0563.4.1

tmbi-4

23 X

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B0563.4

B0563.4.2

tmbi-4

23 X

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B0563.6

B0563.6a

B0563.6

23 X

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B0563.6

B0563.6b.1

B0563.6

23 X

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B0563.6

B0563.6b.2

B0563.6

23 X

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B0563.6

B0563.6c

B0563.6

23 X

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C01C10.1

clc-2

23 X

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clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia. claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes. clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein. [Source: WormBase]

C01C10.3

C01C10.3.1

acl-12

23 X

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C01C10.3

C01C10.3.2

acl-12

23 X

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C01C10.4

clc-5

23 X

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clc-5 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia. CLC-5 is worm-specific, with obvious homologs only in C. elegans. CLC-5 has no obvious function in mass RNAi assays. claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. [Source: WormBase]

C01C4.1

nlp-1

23 X

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nlp-1 encodes a predicted neuropeptide-like protein of the MSFamide family with similarity to Aplysia californica (sea hare) buccalin, a neuropeptide that regulates acetylcholine-induced muscle contraction. NLP-1 is expressed in the phasmid PHB tail sensory neuron, lateral neurons, head neurons, and the intestine. the precise role of NLP-1 in nervous system function and development is not yet known. [Source: WormBase]

C01C4.3

C01C4.3b

C01C4.3

23 X

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C01C4.3 encodes a serine/threonine protein kinase. [Source: WormBase]

C02B4.1

adt-1

23 X

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The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis. [Source: WormBase]

C02B4.4

23 X

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C02B8.2

fbxc-38

23 X

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C02B8.3

23 X

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C02B8.5

23 X

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C02B8.5 encodes a homolog of the functionally active Fmrf Receptor (FR. CG2114) of D. melanogaster. it is thus possible that C02B8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). [Source: WormBase]

C02B8.6

23 X

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C02C6.2

C02C6.2a

olrn-1

23 X

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olrn-1 encodes, by alternative splicing, two isoforms of a transmembrane protein required for differentiation of the AWC[ON] neuron, expression of str-2 in AWC[ON], adaptation to benzaldehyde, chemotaxis to butanone, and enhancement of chemotaxis to butanone by the presence of food. OLRN-1 is orthologous to Drosophila melanogaster RAW and Schistosoma japonicum SJCHGC05616. while OLRN-1 has orthologs in nematodes, trematodes, and arthropods, its has no obvious chordate homologs. OLRN-6 is expressed in many pharyngeal neurons and some head neurons, but is required solely in the AWC[ON] neuron for butanone enhancement. OLRN-6's function in butanone enhancement is both serotonin- and dopamine-independent, and appears to also act in chemotactic enhancement of 2,3-pentanedione and isoamyl alcohol. by orthology with RAW, OLRN-6 is predicted to inhibit JNK-1 signalling, which may in turn allow the asymmetrical AWC[ON] fate to emerge. [Source: WormBase]

C02C6.2

C02C6.2b

olrn-1

23 X

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C02D4.1

jud-4

23 X

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jud-4 encodes an unfamiliar protein, putatively secreted, that is required both for normal sensitivity to ethanol and for survival after freezing and thawing. JUD-4 is expressed in hypodermis and vulval muscles. JUD-4 is orthologous to Brugia malayi Bm1_40315, but lacks obvious orthologies to non-nematode proteins. JUD-4's C-terminal domain has possible similarity to F40E10.5, and to proteins such as human HOMER1. jud-4(ys18) mutants show delayed sensitivity to ethanol levels that rapidly paralyze normal worms, but do not survive freezing and rethawing as does wild-type. JUD-4 has no obvious function in mass RNAi assays. [Source: WormBase]

C02F12.1

C02F12.1b

tsp-17

23 X

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C02F12.3

C02F12.3.1

C02F12.3

23 X

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C02F12.3

C02F12.3.2

C02F12.3

23 X

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C02F12.3

C02F12.3.3

C02F12.3

23 X

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C02F12.9

23 X

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C02H7.2

npr-19

23 X

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C02H7.3

C02H7.3a

aex-3

23 X

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aex-3 encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584). AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively. AEX-3 is also required for egg laying and locomotion. AEX-3 is expressed in nearly all neurons. [Source: WormBase]

C03A3.1

C03A3.1a

C03A3.1

23 X

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C03A3.1

C03A3.1b

C03A3.1

23 X

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C03A3.2

C03A3.2.1

C03A3.2

23 X

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C03B1.13

23 X

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C03B1.1

23 X

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C03B1.5

23 X

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C03B1.7

23 X

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C03B1.9

23 X

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C03F11.1

23 X

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C03F11.4

C03F11.4.1

C03F11.4

23 X

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C03F11.4

C03F11.4.2

C03F11.4

23 X

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C03F11.4

C03F11.4.3

C03F11.4

23 X

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C03H12.1

23 X

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C04A11.1

23 X

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C04A11.4

adm-2

23 X

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adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family). like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. [Source: WormBase]

C04B4.1

C04B4.1.1

C04B4.1

23 X

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C04B4.1

C04B4.1.2

C04B4.1

23 X

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C04B4.4

23 X

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C04C11.2

C04C11.2.1

arrd-25

23 X

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C04C11.2

C04C11.2.2

arrd-25

23 X

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C04E7.3

23 X

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C04E7.4

23 X

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C04F6.1

vit-5

23 X

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vit-5 encodes a vitellogenin, a lipid-binding protein precursor related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent. by homology, VIT-5 is predicted to function as a lipid transport protein. loss of vit-5 activity via large-scale RNA-mediated interference (RNAi) screens indicates that VIT-5 is required for embryogenesis and normal rates of postembryonic growth. VIT-5 is a major yolk component and is expressed exclusively in the adult hermaphrodite intestine from which it is secreted into the pseudocoelomic space and taken up by oocytes. [Source: WormBase]

C04F6.3

C04F6.3.1

cht-1

23 X

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cht-1 encodes a chitinase orthologous to human chitinase-1 (OMIM:600031, mutations are associated with chitotriosidase deficiency). CHT-1 is predicted to function as an extracellular O-glycosyl hydrolase that hydrolyzes the glycosidic bond between two or more carbohydrates. in C. elegans, CHT-1 may play a role in embryogenesis, and may also be required for cuticle degradation during molting and degradation of chitin-containing pathogens as part of a host defense mechanism. [Source: WormBase]

C04F6.3

C04F6.3.2

cht-1

23 X

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C04F6.5

dhs-27

23 X

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dhs-27 encodes a short-chain dehydrogenase predicted to be mitochondrial. [Source: WormBase]

C04F6.7

23 X

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C05A9.1

C05A9.1a

pgp-5

23 X

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pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily. by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins. however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. [Source: WormBase]

C05A9.1

C05A9.1b

pgp-5

23 X

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C05C9.1

23 X

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C05D9.1

C05D9.1.1

snx-1

23 X

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C05D9.1

C05D9.1.2

snx-1

23 X

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C05D9.1

C05D9.1.3

snx-1

23 X

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C05D9.2

C05D9.2.1

lmp-2

23 X

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lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase]

C05D9.2

C05D9.2.2

lmp-2

23 X

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lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase]

C05D9.2

C05D9.2.3

lmp-2

23 X

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lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase]

C05D9.7

23 X

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C05E11.2

23 X

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C05E11.4

amt-1

23 X

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amt-1 encodes a transmembrane transporter that by homology, is predicted to transport ammonium ions across the plasma membrane. as loss of amt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of AMT-1 in C. elegans development and/or behavior is not yet known. [Source: WormBase]

C05G5.4

C05G5.4.1

C05G5.4

23 X

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C05G5.4

C05G5.4.2

C05G5.4

23 X

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C06E2.1

23 X

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C06G1.1

C06G1.1a

C06G1.1

23 X

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C06G1.1

C06G1.1b

C06G1.1

23 X

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C06G1.2

23 X

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C06G1.4

C06G1.4.1

ain-1

23 X

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ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]

C06G1.4

C06G1.4.2

ain-1

23 X

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C07A12.3

C07A12.3a

nhr-35

23 X

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