| Gene ID | Transcript ID | Common Gene Name | # of miRNA targets for specified miRNAs | Chromosome | Strand Direction | Transcript Link to view miRNA target predictions | Gene Link | Description |
|---|---|---|---|---|---|---|---|---|
| AC8.10 | AC8.10 | AC8.10 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| AC8.12 | AC8.12 | AC8.12 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| AC8.3 | AC8.3 | AC8.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| AC8.7 | AC8.7 | AC8.7 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| AH9.2 | AH9.2 | crn-4 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0198.1 | B0198.1 | tsp-20 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0198.3 | B0198.3a | B0198.3 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0272.1 | B0272.1 | tbb-4 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0302.1 | B0302.1a.1 | kin-25 | 3 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase] |
| B0302.1 | B0302.1a.2 | kin-25 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase] |
| B0302.1 | B0302.1b | kin-25 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase] |
| B0310.2 | B0310.2.1 | B0310.2 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0310.5 | B0310.5 | ugt-46 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0403.2 | B0403.2 | ubc-17 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| B0403.3 | B0403.3 | B0403.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0403.5 | B0403.5 | B0403.5 | 3 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| B0403.6 | B0403.6 | B0403.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0410.2 | B0410.2a | vang-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase] |
| B0410.2 | B0410.2b | vang-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase] |
| B0416.1 | B0416.1 | B0416.1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| B0416.3 | B0416.3 | B0416.3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| B0416.5 | B0416.5a | B0416.5 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0416.5 | B0416.5b | B0416.5 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0416.6 | B0416.6 | gly-13 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates. gly-13 is expressed throughout development in many cell types. gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14. [Source: WormBase] |
| B0563.2 | B0563.2 | tsp-11 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| B0563.6 | B0563.6a | B0563.6 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| B0563.6 | B0563.6b.1 | B0563.6 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| B0563.6 | B0563.6b.2 | B0563.6 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| B0563.6 | B0563.6c | B0563.6 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C01C10.1 | C01C10.1 | clc-2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia. claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes. clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein. [Source: WormBase] |
| C01C10.3 | C01C10.3.1 | acl-12 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C01C10.3 | C01C10.3.2 | acl-12 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C01C4.3 | C01C4.3b | C01C4.3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | C01C4.3 encodes a serine/threonine protein kinase. [Source: WormBase] |
| C02B4.1 | C02B4.1 | adt-1 | 5 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis. [Source: WormBase] |
| C02B4.2 | C02B4.2 | nhr-17 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | nhr-17 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators. nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain. [Source: WormBase] |
| C02B4.4 | C02B4.4 | C02B4.4 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C02B8.1 | C02B8.1.1 | C02B8.1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C02B8.1 | C02B8.1.2 | C02B8.1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C02B8.5 | C02B8.5 | C02B8.5 | 4 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | C02B8.5 encodes a homolog of the functionally active Fmrf Receptor (FR. CG2114) of D. melanogaster. it is thus possible that C02B8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). [Source: WormBase] |
| C02B8.6 | C02B8.6 | C02B8.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C02C6.1 | C02C6.1a | dyn-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase] |
| C02C6.1 | C02C6.1b | dyn-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase] |
| C02C6.2 | C02C6.2a | olrn-1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | olrn-1 encodes, by alternative splicing, two isoforms of a transmembrane protein required for differentiation of the AWC[ON] neuron, expression of str-2 in AWC[ON], adaptation to benzaldehyde, chemotaxis to butanone, and enhancement of chemotaxis to butanone by the presence of food. OLRN-1 is orthologous to Drosophila melanogaster RAW and Schistosoma japonicum SJCHGC05616. while OLRN-1 has orthologs in nematodes, trematodes, and arthropods, its has no obvious chordate homologs. OLRN-6 is expressed in many pharyngeal neurons and some head neurons, but is required solely in the AWC[ON] neuron for butanone enhancement. OLRN-6's function in butanone enhancement is both serotonin- and dopamine-independent, and appears to also act in chemotactic enhancement of 2,3-pentanedione and isoamyl alcohol. by orthology with RAW, OLRN-6 is predicted to inhibit JNK-1 signalling, which may in turn allow the asymmetrical AWC[ON] fate to emerge. [Source: WormBase] |
| C02C6.2 | C02C6.2b | olrn-1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | olrn-1 encodes, by alternative splicing, two isoforms of a transmembrane protein required for differentiation of the AWC[ON] neuron, expression of str-2 in AWC[ON], adaptation to benzaldehyde, chemotaxis to butanone, and enhancement of chemotaxis to butanone by the presence of food. OLRN-1 is orthologous to Drosophila melanogaster RAW and Schistosoma japonicum SJCHGC05616. while OLRN-1 has orthologs in nematodes, trematodes, and arthropods, its has no obvious chordate homologs. OLRN-6 is expressed in many pharyngeal neurons and some head neurons, but is required solely in the AWC[ON] neuron for butanone enhancement. OLRN-6's function in butanone enhancement is both serotonin- and dopamine-independent, and appears to also act in chemotactic enhancement of 2,3-pentanedione and isoamyl alcohol. by orthology with RAW, OLRN-6 is predicted to inhibit JNK-1 signalling, which may in turn allow the asymmetrical AWC[ON] fate to emerge. [Source: WormBase] |
| C02D4.2 | C02D4.2a | ser-2 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | ser-2 encodes at least four tyramine 7-transmembrane domain receptors (GPCRs), by alternative splicing from three different promoters, that have distinct but partially overlapping expression patterns. ser-2 has at least three alternative promoters that drive SER-2 expression in a set of sensory, inter- and motor neurons (e.g., AIY, AIZ, and RIA) adding up to ~10% of all neurons in the nervous system, as well as pharyngeal cells and head muscles. the deletion ser-2(pk1397) has no obvious mutant phenotype. LIM-4 is required for SER-2 expression, and MAB-23 is required for SER-2 expression at normally high levels. [Source: WormBase] |
| C02D4.2 | C02D4.2b | ser-2 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | ser-2 encodes at least four tyramine 7-transmembrane domain receptors (GPCRs), by alternative splicing from three different promoters, that have distinct but partially overlapping expression patterns. ser-2 has at least three alternative promoters that drive SER-2 expression in a set of sensory, inter- and motor neurons (e.g., AIY, AIZ, and RIA) adding up to ~10% of all neurons in the nervous system, as well as pharyngeal cells and head muscles. the deletion ser-2(pk1397) has no obvious mutant phenotype. LIM-4 is required for SER-2 expression, and MAB-23 is required for SER-2 expression at normally high levels. [Source: WormBase] |
| C02D4.2 | C02D4.2e | ser-2 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | ser-2 encodes at least four tyramine 7-transmembrane domain receptors (GPCRs), by alternative splicing from three different promoters, that have distinct but partially overlapping expression patterns. ser-2 has at least three alternative promoters that drive SER-2 expression in a set of sensory, inter- and motor neurons (e.g., AIY, AIZ, and RIA) adding up to ~10% of all neurons in the nervous system, as well as pharyngeal cells and head muscles. the deletion ser-2(pk1397) has no obvious mutant phenotype. LIM-4 is required for SER-2 expression, and MAB-23 is required for SER-2 expression at normally high levels. [Source: WormBase] |
| C02D4.2 | C02D4.2f | ser-2 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | ser-2 encodes at least four tyramine 7-transmembrane domain receptors (GPCRs), by alternative splicing from three different promoters, that have distinct but partially overlapping expression patterns. ser-2 has at least three alternative promoters that drive SER-2 expression in a set of sensory, inter- and motor neurons (e.g., AIY, AIZ, and RIA) adding up to ~10% of all neurons in the nervous system, as well as pharyngeal cells and head muscles. the deletion ser-2(pk1397) has no obvious mutant phenotype. LIM-4 is required for SER-2 expression, and MAB-23 is required for SER-2 expression at normally high levels. [Source: WormBase] |
| C02F12.3 | C02F12.3.1 | C02F12.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C02F12.4 | C02F12.4 | tag-52 | 4 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C02F12.5 | C02F12.5 | C02F12.5 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | C02F12.5 encodes a putatively secreted protein with a Kunitz/bovine pancreatic trypsin inhibitor domain. C02F12.5 has no obvious function in mass RNAi assays. [Source: WormBase] |
| C02F12.7 | C02F12.7 | tag-278 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C02H7.1 | C02H7.1 | dyf-11 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | dyf-11 encodes a conserved protein orthologous to the human microtubule-binding protein MIP-T3 and that contains a lysine-rich region and a C-terminal coiled-coil domain present in a number of intraflagellar transport (IFT) complex B proteins. DYF-11 activity is required continuously in sensory neurons for formation of medial and distal ciliary segments and thus, for normal sensory cilium morphology and function and chemotaxis. a dyf-11::gfp promoter fusion is expressed in all ciliated sensory neurons as well as in the AQR, PQR, ADE, and PDR neurons. a DYF-11::GFP protein fusion is detected throughout the cilium and appears to localize to IFT-B particles in a manner consistent with an early role in IFT-B particle assembly. dyf-11 expression in ciliated neurons is dependent upon the presence of the DAF-19 RFX transcription factor. [Source: WormBase] |
| C02H7.3 | C02H7.3a | aex-3 | 3 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | aex-3 encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584). AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively. AEX-3 is also required for egg laying and locomotion. AEX-3 is expressed in nearly all neurons. [Source: WormBase] |
| C03A3.3 | C03A3.3 | C03A3.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C03F11.1 | C03F11.1 | C03F11.1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C03H12.1 | C03H12.1 | C03H12.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C04A11.3 | C04A11.3 | gck-4 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C04A11.4 | C04A11.4 | adm-2 | 3 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family). like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. [Source: WormBase] |
| C04B4.2 | C04B4.2 | C04B4.2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C04E7.4 | C04E7.4 | C04E7.4 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C04F6.2 | C04F6.2 | C04F6.2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C04F6.4 | C04F6.4a | unc-78 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | The unc-78 gene encodes a homolog of actin-interacting protein 1 (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils. [Source: WormBase] |
| C04F6.5 | C04F6.5 | dhs-27 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | dhs-27 encodes a short-chain dehydrogenase predicted to be mitochondrial. [Source: WormBase] |
| C04F6.7 | C04F6.7 | C04F6.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C05A9.2 | C05A9.2 | C05A9.2 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C05C9.3 | C05C9.3 | C05C9.3 | 5 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). [Source: WormBase] |
| C05D9.2 | C05D9.2.1 | lmp-2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase] |
| C05D9.2 | C05D9.2.2 | lmp-2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase] |
| C05D9.2 | C05D9.2.3 | lmp-2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase] |
| C05D9.4 | C05D9.4 | C05D9.4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C05E7.2 | C05E7.2 | C05E7.2 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C05G5.1 | C05G5.1 | C05G5.1 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C05G5.5 | C05G5.5 | C05G5.5 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C06E2.1 | C06E2.1 | C06E2.1 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C06E2.7 | C06E2.7 | ubc-22 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | ubc-22 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae UBC8 and human UBC1/HIP2 (Huntingtin interacting protein 2, OMIM:602846) which are involved in regulating fructose-1,6-bisphosphatase and huntingtin catabolism, respectively. by homology, UBC-22 is likely required for covalent attachment of ubiquitin to select target proteins to facilitate their degradation. however, as loss of UBC-22 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UBC-22 in C. elegans development and/or behavior is not yet known. [Source: WormBase] |
| C06G1.2 | C06G1.2 | C06G1.2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C06G1.4 | C06G1.4.1 | ain-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase] |
| C06G1.4 | C06G1.4.2 | ain-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase] |
| C07A12.1 | C07A12.1a | ham-2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase] |
| C07A12.1 | C07A12.1b | ham-2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase] |
| C07A12.1 | C07A12.1c | ham-2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase] |
| C07A12.3 | C07A12.3a | nhr-35 | 3 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A12.5 | C07A12.5a | spr-3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A12.7 | C07A12.7a.1 | C07A12.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A12.7 | C07A12.7a.2 | C07A12.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A12.7 | C07A12.7b | C07A12.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A12.7 | C07A12.7c.1 | C07A12.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C07B5.4 | C07B5.4a.1 | C07B5.4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C07B5.4 | C07B5.4a.2 | C07B5.4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C07B5.4 | C07B5.4b.1 | C07B5.4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C07B5.4 | C07B5.4b.2 | C07B5.4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C08A9.1 | C08A9.1 | sod-3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan. sod-3 mRNA levels are diminished by mutation of daf-16 and chromatin immunoprecipitation (ChIP) studies demonstrate that DAF-16 can directly bind the sod-3 promoter. heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress. [Source: WormBase] |
| C08A9.3 | C08A9.3a | C08A9.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C08A9.3 | C08A9.3b | C08A9.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C08A9.9 | C08A9.9.1 | C08A9.9 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C08A9.9 | C08A9.9.2 | C08A9.9 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C09B8.6 | C09B8.6a | hsp-25 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | hsp-25 encodes a member of the small heat shock family of proteins. HSP-25 is expressed throughout development and in vitro, exhibits chaperone activity. HSP-25 localizes to: 1) dense bodies and M lines in body wall muscle, 2) the lining of the pharynx, and 3) to cell-cell junctions in the spermathecal wall. consistent with a role in myofibril organization, HSP-25 binds vinculin and alpha-actinin in vitro. [Source: WormBase] |
| C09B8.6 | C09B8.6b | hsp-25 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | hsp-25 encodes a member of the small heat shock family of proteins. HSP-25 is expressed throughout development and in vitro, exhibits chaperone activity. HSP-25 localizes to: 1) dense bodies and M lines in body wall muscle, 2) the lining of the pharynx, and 3) to cell-cell junctions in the spermathecal wall. consistent with a role in myofibril organization, HSP-25 binds vinculin and alpha-actinin in vitro. [Source: WormBase] |
| C09B8.6 | C09B8.6c.1 | hsp-25 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | hsp-25 encodes a member of the small heat shock family of proteins. HSP-25 is expressed throughout development and in vitro, exhibits chaperone activity. HSP-25 localizes to: 1) dense bodies and M lines in body wall muscle, 2) the lining of the pharynx, and 3) to cell-cell junctions in the spermathecal wall. consistent with a role in myofibril organization, HSP-25 binds vinculin and alpha-actinin in vitro. [Source: WormBase] |