| Gene ID | Transcript ID | Common Gene Name | # of miRNA targets for specified miRNAs | Chromosome | Strand Direction | Transcript Link to view miRNA target predictions | Gene Link | Description |
|---|---|---|---|---|---|---|---|---|
| AC8.10 | AC8.10 | AC8.10 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| AC8.3 | AC8.3 | AC8.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0198.1 | B0198.1 | tsp-20 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0198.3 | B0198.3a | B0198.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0272.4 | B0272.4 | B0272.4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| B0302.1 | B0302.1a.1 | kin-25 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase] |
| B0302.1 | B0302.1a.2 | kin-25 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase] |
| B0302.1 | B0302.1b | kin-25 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase] |
| B0344.2 | B0344.2 | wrt-9 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | wrt-9 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of proline-rich, low-complexity sequence. the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. WRT-9 has no obvious function in RNAi assays. [Source: WormBase] |
| B0395.1 | B0395.1 | nhx-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | nhx-1 encodes a sodium/proton exchanger expressed intracellularly within hypodermal and muscle cells. NHX-1 is required for embryonic viability, and is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton. [Source: WormBase] |
| B0395.2 | B0395.2 | mboa-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | mboa-1 encodes a putative acyl-Coenzyme A:cholesterol ('sterol') O-acyltransferase, orthologous to human SOAT1 (OMIM:102642). MBOA-1 is required for normal locomotion and normally long lifespan in mass RNAi assays. mboa-1 is expressed in the seam cells and nervous systems of larvae and adults, and in the adult reproductive system. [Source: WormBase] |
| B0410.2 | B0410.2b | vang-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase] |
| B0563.4 | B0563.4.1 | tmbi-4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| B0563.4 | B0563.4.2 | tmbi-4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C01C10.3 | C01C10.3.1 | acl-12 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C01C10.3 | C01C10.3.2 | acl-12 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C02B4.2 | C02B4.2 | nhr-17 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | nhr-17 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators. nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain. [Source: WormBase] |
| C02H7.1 | C02H7.1 | dyf-11 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | dyf-11 encodes a conserved protein orthologous to the human microtubule-binding protein MIP-T3 and that contains a lysine-rich region and a C-terminal coiled-coil domain present in a number of intraflagellar transport (IFT) complex B proteins. DYF-11 activity is required continuously in sensory neurons for formation of medial and distal ciliary segments and thus, for normal sensory cilium morphology and function and chemotaxis. a dyf-11::gfp promoter fusion is expressed in all ciliated sensory neurons as well as in the AQR, PQR, ADE, and PDR neurons. a DYF-11::GFP protein fusion is detected throughout the cilium and appears to localize to IFT-B particles in a manner consistent with an early role in IFT-B particle assembly. dyf-11 expression in ciliated neurons is dependent upon the presence of the DAF-19 RFX transcription factor. [Source: WormBase] |
| C03B1.1 | C03B1.1 | C03B1.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C03B1.4 | C03B1.4 | C03B1.4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C03F11.1 | C03F11.1 | C03F11.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C03H12.1 | C03H12.1 | C03H12.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C04A11.3 | C04A11.3 | gck-4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C04F6.3 | C04F6.3.1 | cht-1 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | cht-1 encodes a chitinase orthologous to human chitinase-1 (OMIM:600031, mutations are associated with chitotriosidase deficiency). CHT-1 is predicted to function as an extracellular O-glycosyl hydrolase that hydrolyzes the glycosidic bond between two or more carbohydrates. in C. elegans, CHT-1 may play a role in embryogenesis, and may also be required for cuticle degradation during molting and degradation of chitin-containing pathogens as part of a host defense mechanism. [Source: WormBase] |
| C04F6.3 | C04F6.3.2 | cht-1 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | cht-1 encodes a chitinase orthologous to human chitinase-1 (OMIM:600031, mutations are associated with chitotriosidase deficiency). CHT-1 is predicted to function as an extracellular O-glycosyl hydrolase that hydrolyzes the glycosidic bond between two or more carbohydrates. in C. elegans, CHT-1 may play a role in embryogenesis, and may also be required for cuticle degradation during molting and degradation of chitin-containing pathogens as part of a host defense mechanism. [Source: WormBase] |
| C05A9.1 | C05A9.1a | pgp-5 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily. by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins. however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. [Source: WormBase] |
| C05A9.1 | C05A9.1b | pgp-5 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily. by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins. however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. [Source: WormBase] |
| C05D9.3 | C05D9.3 | C05D9.3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C05D9.7 | C05D9.7 | C05D9.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C05D9.9 | C05D9.9b | C05D9.9 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C05E7.4 | C05E7.4 | C05E7.4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C05G5.2 | C05G5.2 | C05G5.2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C06G1.1 | C06G1.1b | C06G1.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C06G1.4 | C06G1.4.1 | ain-1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase] |
| C06G1.4 | C06G1.4.2 | ain-1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase] |
| C07A12.3 | C07A12.3a | nhr-35 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A12.5 | C07A12.5a | spr-3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A12.7 | C07A12.7a.1 | C07A12.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A12.7 | C07A12.7a.2 | C07A12.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A12.7 | C07A12.7b | C07A12.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A12.7 | C07A12.7c.1 | C07A12.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A12.7 | C07A12.7c.2 | C07A12.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A4.3 | C07A4.3 | C07A4.3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C07B5.5 | C07B5.5 | nuc-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | The nuc-1 gene encodes a DNase II homolog similar to mammalian and Drosophila DNaseII enzymes and is required for DNA degradation during apoptosis as well as for degradation of dietary DNA during normal feeding. during apoptosis, NUC-1 functions in apoptotic cells at an intermediate stage of DNA degradation, after the killing step, but prior to cell-corpse engulfment. [Source: WormBase] |
| C11H1.4 | C11H1.4a | prx-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | prx-1 encodes a predicted peroxin, a subfamily 2 member of the AAA (ATPases Associated with diverse cellular Activities) family that affects growth in one large-scale RNAi screen. expressed in intestinal cells throughout development. [Source: WormBase] |
| C14A11.7 | C14A11.7 | ssr-2 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C14H10.1 | C14H10.1.1 | C14H10.1 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C14H10.1 | C14H10.1.2 | C14H10.1 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C15B12.4 | C15B12.4 | C15B12.4 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C15H9.1 | C15H9.1 | nnt-1 | 3 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | nnt-1 encodes a proton-pumping nicotinamide nucleotide transhydrogenase predicted to be mitochondrial. [Source: WormBase] |
| C15H9.3 | C15H9.3 | C15H9.3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C16B8.1 | C16B8.1.1 | lin-18 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | lin-18 encodes a predicted receptor tyrosine kinase that is a member of the Ryk/Derailed family of tyrosine kinase-related receptors (OMIM:600524, mutations in humans are associated with cleft palate). in C. elegans, LIN-18 is required for establishing the polarity of the secondary vulval cell lineage produced by the P7.p vulval precursor cell. LIN-18 may be a receptor for Wnt-like signaling molecules, and in vulval development appears to function independently of, but in parallel with, LIN-17, a Frizzled-like Wnt receptor, also required for proper orientation of the P7.p lineage. a lin-18 reporter gene is expressed in body wall muscle, neurons, and the developing vulva. in the vulva, expression is detected in P5.p, P6.p, and P7.p and all of their descendants during the L3 and L4 larval stages. [Source: WormBase] |
| C16B8.1 | C16B8.1.2 | lin-18 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | lin-18 encodes a predicted receptor tyrosine kinase that is a member of the Ryk/Derailed family of tyrosine kinase-related receptors (OMIM:600524, mutations in humans are associated with cleft palate). in C. elegans, LIN-18 is required for establishing the polarity of the secondary vulval cell lineage produced by the P7.p vulval precursor cell. LIN-18 may be a receptor for Wnt-like signaling molecules, and in vulval development appears to function independently of, but in parallel with, LIN-17, a Frizzled-like Wnt receptor, also required for proper orientation of the P7.p lineage. a lin-18 reporter gene is expressed in body wall muscle, neurons, and the developing vulva. in the vulva, expression is detected in P5.p, P6.p, and P7.p and all of their descendants during the L3 and L4 larval stages. [Source: WormBase] |
| C16B8.2 | C16B8.2.1 | C16B8.2 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C16B8.2 | C16B8.2.2 | C16B8.2 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17G1.3 | C17G1.3a | ugt-23 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17G1.3 | C17G1.3b.1 | ugt-23 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17G1.3 | C17G1.3b.2 | ugt-23 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17G1.4 | C17G1.4a | nra-3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17G1.4 | C17G1.4b | nra-3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17H11.6 | C17H11.6a | C17H11.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17H11.6 | C17H11.6b | C17H11.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17H11.6 | C17H11.6c.1 | C17H11.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17H11.6 | C17H11.6c.2 | C17H11.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17H11.6 | C17H11.6c.3 | C17H11.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17H11.6 | C17H11.6d | C17H11.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C18B12.2 | C18B12.2 | C18B12.2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | C18B12.2 encodes a G-protein-coupled receptor (GPCR) that is a member of the secretin family (also known as family B or family 2) of GPCRs. [Source: WormBase] |
| C18B2.1 | C18B2.1 | C18B2.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C18B2.6 | C18B2.6 | C18B2.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C23H4.4 | C23H4.4a | C23H4.4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C23H4.7 | C23H4.7 | C23H4.7 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C24A3.6 | C24A3.6.1 | twk-18 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | twk-18 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains. TWK-18 was originally defined by gain-of-function mutations that result in embryonic lethality at the two-fold stage, locomotion defects, longer than normal body length, abnormal egg-laying, and temperature-sensitive paralysis. as loss of TWK-18 function via reversion or RNA-mediated interference does not result in any abnormalities, TWK-18 likely functions redundantly with other TWK channels. TWK-18 can function as an outwardly rectifying K+ channel, and is activated by temperature increases, thus making it a temperature-gated channel. TWK-18 is expressed in body wall muscle. [Source: WormBase] |
| C24A3.6 | C24A3.6.2 | twk-18 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | twk-18 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains. TWK-18 was originally defined by gain-of-function mutations that result in embryonic lethality at the two-fold stage, locomotion defects, longer than normal body length, abnormal egg-laying, and temperature-sensitive paralysis. as loss of TWK-18 function via reversion or RNA-mediated interference does not result in any abnormalities, TWK-18 likely functions redundantly with other TWK channels. TWK-18 can function as an outwardly rectifying K+ channel, and is activated by temperature increases, thus making it a temperature-gated channel. TWK-18 is expressed in body wall muscle. [Source: WormBase] |
| C24A3.6 | C24A3.6.3 | twk-18 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | twk-18 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains. TWK-18 was originally defined by gain-of-function mutations that result in embryonic lethality at the two-fold stage, locomotion defects, longer than normal body length, abnormal egg-laying, and temperature-sensitive paralysis. as loss of TWK-18 function via reversion or RNA-mediated interference does not result in any abnormalities, TWK-18 likely functions redundantly with other TWK channels. TWK-18 can function as an outwardly rectifying K+ channel, and is activated by temperature increases, thus making it a temperature-gated channel. TWK-18 is expressed in body wall muscle. [Source: WormBase] |
| C24A8.3 | C24A8.3 | pqn-15 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). [Source: WormBase] |
| C25A11.4 | C25A11.4a | ajm-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo. AJM-1 contains a coiled-coil motif. AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo. AJM-1 is mislocalized in a dlg-1(RNAi) background. LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia. CLC-1 colocalizes with AJM-1. vab-9 mutations enhance the adhesion defects of ajm-1 mutants. ajm-1 is expressed at the apical borders of all epithelia. [Source: WormBase] |
| C25A11.4 | C25A11.4d | ajm-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo. AJM-1 contains a coiled-coil motif. AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo. AJM-1 is mislocalized in a dlg-1(RNAi) background. LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia. CLC-1 colocalizes with AJM-1. vab-9 mutations enhance the adhesion defects of ajm-1 mutants. ajm-1 is expressed at the apical borders of all epithelia. [Source: WormBase] |
| C25B8.1 | C25B8.1a | kqt-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | kqt-1 encodes one of three C. elegans KCNQ-like potassium channel subunits that, with respect to humans, is most similar to the KCNQ2-5 subfamily of channel proteins. although loss of KQT-1 activity via large-scale RNAi screens results in no obvious abnormalities, KQT-1 likely functions to regulate cellular excitability as expression of KQT-1 in Xenopus oocytes can produce K+ channel currents that functionally resemble vertebrate M-currents. activity of these KQT-1 channels can be suppressed by coexpression with the human M1 muscarinic receptor and treatment with diacylglycerol analogs. a KQT-1::GFP translational fusion is expressed in pharyngeal muscle cells, in the anterior and posterior mechanosensory neurons ALM and PLM, and in some head neurons. [Source: WormBase] |
| C25B8.1 | C25B8.1b | kqt-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | kqt-1 encodes one of three C. elegans KCNQ-like potassium channel subunits that, with respect to humans, is most similar to the KCNQ2-5 subfamily of channel proteins. although loss of KQT-1 activity via large-scale RNAi screens results in no obvious abnormalities, KQT-1 likely functions to regulate cellular excitability as expression of KQT-1 in Xenopus oocytes can produce K+ channel currents that functionally resemble vertebrate M-currents. activity of these KQT-1 channels can be suppressed by coexpression with the human M1 muscarinic receptor and treatment with diacylglycerol analogs. a KQT-1::GFP translational fusion is expressed in pharyngeal muscle cells, in the anterior and posterior mechanosensory neurons ALM and PLM, and in some head neurons. [Source: WormBase] |
| C25B8.3 | C25B8.3a | cpr-6 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C25B8.3 | C25B8.3b | cpr-6 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C25B8.3 | C25B8.3c | cpr-6 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C25F6.4 | C25F6.4 | ddr-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | The C25F6.4 gene encodes a protein tyrosine kinase homolog that is also homologous to human RS1. [Source: WormBase] |
| C25G6.1 | C25G6.1 | C25G6.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C25G6.3 | C25G6.3 | C25G6.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C25G6.5 | C25G6.5 | npr-11 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C26B9.1 | C26B9.1a | C26B9.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C26B9.7 | C26B9.7 | C26B9.7 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C27C12.2 | C27C12.2 | egrh-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | C27C12.2 is orthologous to the human gene BA436D10.3 (EARLY GROWTH RESPONSE 2 (KROX-20 (DROSOPHILA) HOMOLOG)) (EGR2. OMIM:129010), which when mutated leads to disease. [Source: WormBase] |
| C29F7.1 | C29F7.1 | C29F7.1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C29F7.3 | C29F7.3 | C29F7.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C29F7.5 | C29F7.5 | fkh-4 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | fkh-4 encodes a member of the forkhead domain transcription factor family. [Source: WormBase] |
| C30E1.6 | C30E1.6 | C30E1.6 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C30G4.3 | C30G4.3 | gcy-11 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C31E10.6 | C31E10.6 | C31E10.6 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C31E10.8 | C31E10.8 | tbc-19 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C31H2.2 | C31H2.2 | dpy-8 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | dpy-8 encodes a collagen with a nematode-specific N-terminal domain that is required for normal body morphology and (perhaps) for a normal embryonic cell division rate. dpy-8 interacts genetically with emb-5 and glp-1. [Source: WormBase] |
| C31H2.3 | C31H2.3 | C31H2.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C32A9.1 | C32A9.1 | C32A9.1 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C33D12.2 | C33D12.2 | C33D12.2 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | C33D12.2 encodes a predicted transmembrane protein orthologous to human ACDP1-ACDP4 and S. cerevisiae MAM3, and paralogous to C01H6.6, C52D10.12, M02F4.3, R04E5.2, and R13G10.4. by orthology with MAM3, C33D12.2 may participate in metal homoeostasis. C33D12.2 is expressed in intestine, body wall muscle, nervous system (including ventral and dorsal nerve cords and head neurons), and adult vulval muscle and reproductive system. C33D12.2, MAM3, and ACDP1-ACDP4 belong to a family of proteins (sharing an ACD domain) from bacteria, yeast, plants, and metazoa. murine Acdp1 is a plasma membrane protein. bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux. C33D12.2 has no obvious function in RNAi assays. [Source: WormBase] |