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Genome: Caenorhabditis Elegans | mRNA | miRBase 18 (Nov. 2011), ENSEMBL 65 (Dec. 2011) and RNA22v1.0
Description: List of transcripts that are targeted by all of the below miRNA identifiers simultaneously
miRNA's: cel-miR-66-5p (MIMAT0000038)
Filtering By: Base pair min value: 12 | Folding energy max value (Kcal/mol): -21 | Min miRNA targets: 1


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Gene IDTranscript IDCommon Gene Name# of miRNA targets
for specified miRNAs
ChromosomeStrand DirectionTranscript Link to view miRNA target predictionsGene LinkDescription
AH9.1AH9.1AH9.1223 XReverseView as cDNA map |
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Ensembl
AH9.2AH9.2crn-4123 XReverseView as cDNA map |
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Ensembl
AH9.4AH9.4AH9.4123 XReverseView as cDNA map |
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Ensembl
B0302.4B0302.4B0302.4123 XReverseView as cDNA map |
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Ensembl
B0395.2B0395.2mboa-1123 XForwardView as cDNA map |
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Ensembl
mboa-1 encodes a putative acyl-Coenzyme A:cholesterol ('sterol') O-acyltransferase, orthologous to human SOAT1 (OMIM:102642). MBOA-1 is required for normal locomotion and normally long lifespan in mass RNAi assays. mboa-1 is expressed in the seam cells and nervous systems of larvae and adults, and in the adult reproductive system. [Source: WormBase]
B0395.3B0395.3.1B0395.3123 XReverseView as cDNA map |
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B0395.3 is orthologous to the human gene CHOLINE ACETYLTRANSFERASE ISOFORM R (CHAT. OMIM:118490), which when mutated leads to disease. [Source: WormBase]
B0395.3B0395.3.2B0395.3123 XReverseView as cDNA map |
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Ensembl
B0395.3 is orthologous to the human gene CHOLINE ACETYLTRANSFERASE ISOFORM R (CHAT. OMIM:118490), which when mutated leads to disease. [Source: WormBase]
B0410.1B0410.1B0410.1123 XForwardView as cDNA map |
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B0410.3B0410.3B0410.3123 XReverseView as cDNA map |
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Ensembl
B0416.1B0416.1B0416.1223 XForwardView as cDNA map |
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Ensembl
B0416.5B0416.5aB0416.5323 XReverseView as cDNA map |
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Ensembl
B0416.5B0416.5bB0416.5323 XReverseView as cDNA map |
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Ensembl
C01C10.3C01C10.3.1acl-12123 XReverseView as cDNA map |
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C01C10.3C01C10.3.2acl-12123 XReverseView as cDNA map |
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C02B8.1C02B8.1.1C02B8.1123 XForwardView as cDNA map |
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C02B8.1C02B8.1.2C02B8.1123 XForwardView as cDNA map |
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C02B8.5C02B8.5C02B8.5123 XReverseView as cDNA map |
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C02B8.5 encodes a homolog of the functionally active Fmrf Receptor (FR. CG2114) of D. melanogaster. it is thus possible that C02B8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). [Source: WormBase]
C02B8.6C02B8.6C02B8.6123 XReverseView as cDNA map |
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C02C6.1C02C6.1adyn-1123 XForwardView as cDNA map |
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dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase]
C02C6.1C02C6.1bdyn-1123 XForwardView as cDNA map |
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dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase]
C02C6.2C02C6.2aolrn-1223 XForwardView as cDNA map |
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olrn-1 encodes, by alternative splicing, two isoforms of a transmembrane protein required for differentiation of the AWC[ON] neuron, expression of str-2 in AWC[ON], adaptation to benzaldehyde, chemotaxis to butanone, and enhancement of chemotaxis to butanone by the presence of food. OLRN-1 is orthologous to Drosophila melanogaster RAW and Schistosoma japonicum SJCHGC05616. while OLRN-1 has orthologs in nematodes, trematodes, and arthropods, its has no obvious chordate homologs. OLRN-6 is expressed in many pharyngeal neurons and some head neurons, but is required solely in the AWC[ON] neuron for butanone enhancement. OLRN-6's function in butanone enhancement is both serotonin- and dopamine-independent, and appears to also act in chemotactic enhancement of 2,3-pentanedione and isoamyl alcohol. by orthology with RAW, OLRN-6 is predicted to inhibit JNK-1 signalling, which may in turn allow the asymmetrical AWC[ON] fate to emerge. [Source: WormBase]
C02C6.2C02C6.2bolrn-1123 XForwardView as cDNA map |
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olrn-1 encodes, by alternative splicing, two isoforms of a transmembrane protein required for differentiation of the AWC[ON] neuron, expression of str-2 in AWC[ON], adaptation to benzaldehyde, chemotaxis to butanone, and enhancement of chemotaxis to butanone by the presence of food. OLRN-1 is orthologous to Drosophila melanogaster RAW and Schistosoma japonicum SJCHGC05616. while OLRN-1 has orthologs in nematodes, trematodes, and arthropods, its has no obvious chordate homologs. OLRN-6 is expressed in many pharyngeal neurons and some head neurons, but is required solely in the AWC[ON] neuron for butanone enhancement. OLRN-6's function in butanone enhancement is both serotonin- and dopamine-independent, and appears to also act in chemotactic enhancement of 2,3-pentanedione and isoamyl alcohol. by orthology with RAW, OLRN-6 is predicted to inhibit JNK-1 signalling, which may in turn allow the asymmetrical AWC[ON] fate to emerge. [Source: WormBase]
C02F12.3C02F12.3.1C02F12.3123 XReverseView as cDNA map |
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C02F12.3C02F12.3.2C02F12.3123 XReverseView as cDNA map |
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C02F12.3C02F12.3.3C02F12.3123 XReverseView as cDNA map |
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C02F12.4C02F12.4tag-52123 XReverseView as cDNA map |
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C02H7.3C02H7.3aaex-3323 XReverseView as cDNA map |
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aex-3 encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584). AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively. AEX-3 is also required for egg laying and locomotion. AEX-3 is expressed in nearly all neurons. [Source: WormBase]
C03A3.1C03A3.1bC03A3.1123 XForwardView as cDNA map |
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C03A3.3C03A3.3C03A3.3123 XReverseView as cDNA map |
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C03B1.13C03B1.13C03B1.13123 XReverseView as cDNA map |
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C03B1.7C03B1.7C03B1.7223 XForwardView as cDNA map |
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C03F11.1C03F11.1C03F11.1123 XForwardView as cDNA map |
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C03F11.4C03F11.4.1C03F11.4123 XReverseView as cDNA map |
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C03F11.4C03F11.4.2C03F11.4123 XReverseView as cDNA map |
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C03F11.4C03F11.4.3C03F11.4123 XReverseView as cDNA map |
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C04A11.1C04A11.1C04A11.1323 XForwardView as cDNA map |
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C04A11.4C04A11.4adm-2123 XForwardView as cDNA map |
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adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family). like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. [Source: WormBase]
C04B4.6C04B4.6C04B4.6123 XReverseView as cDNA map |
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C04C11.2C04C11.2.1arrd-25123 XForwardView as cDNA map |
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C04E7.1C04E7.1C04E7.1123 XForwardView as cDNA map |
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C04E7.2C04E7.2sor-3223 XForwardView as cDNA map |
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sor-3 encodes a novel protein that contains an MBT (malignant brain tumor) domain related to the MBT domains found in the Sex comb on midleg (SCM) and Sfmbt Polycomb group proteins. during development, SOR-3 activity is required to specify the correct number of dopaminergic and serotonergic neurons in males, as well as for proper ray neuron axon guidance, distal tip cell migration, and normal body size. SOR-3 activity is necessary for maintaining repression of Hox gene expression, notably that of egl-5 in many head neurons. in regulating neurotransmitter phenotype, sor-3 functions together with sop-2, which also encodes a Polycomb group protein, and members of the TGF-beta signaling pathway. sor-3 and sop-2 also function together to regulate progression through larval development. a SOR-3::GFP reporter fusion is expressed ubiquitously throughout the life cycle and localizes to both the cytoplasm and the nucleus. [Source: WormBase]
C04F6.1C04F6.1vit-5123 XForwardView as cDNA map |
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vit-5 encodes a vitellogenin, a lipid-binding protein precursor related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent. by homology, VIT-5 is predicted to function as a lipid transport protein. loss of vit-5 activity via large-scale RNA-mediated interference (RNAi) screens indicates that VIT-5 is required for embryogenesis and normal rates of postembryonic growth. VIT-5 is a major yolk component and is expressed exclusively in the adult hermaphrodite intestine from which it is secreted into the pseudocoelomic space and taken up by oocytes. [Source: WormBase]
C04F6.5C04F6.5dhs-27123 XReverseView as cDNA map |
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dhs-27 encodes a short-chain dehydrogenase predicted to be mitochondrial. [Source: WormBase]
C05A9.1C05A9.1apgp-5123 XReverseView as cDNA map |
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pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily. by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins. however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. [Source: WormBase]
C05A9.1C05A9.1bpgp-5123 XReverseView as cDNA map |
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pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily. by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins. however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. [Source: WormBase]
C05E11.4C05E11.4amt-1123 XForwardView as cDNA map |
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amt-1 encodes a transmembrane transporter that by homology, is predicted to transport ammonium ions across the plasma membrane. as loss of amt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of AMT-1 in C. elegans development and/or behavior is not yet known. [Source: WormBase]
C05E11.5C05E11.5amt-4123 XForwardView as cDNA map |
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amt-4 encodes a member of the ammonium transporter protein family. [Source: WormBase]
C05E11.7C05E11.7C05E11.7123 XReverseView as cDNA map |
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C05E7.4C05E7.4C05E7.4123 XForwardView as cDNA map |
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C05G5.1C05G5.1C05G5.1223 XReverseView as cDNA map |
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C06G1.1C06G1.1aC06G1.1123 XForwardView as cDNA map |
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C06G1.1C06G1.1bC06G1.1123 XForwardView as cDNA map |
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C06G1.4C06G1.4.1ain-1123 XForwardView as cDNA map |
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ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]
C07A12.1C07A12.1aham-2123 XForwardView as cDNA map |
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The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase]
C07A12.1C07A12.1bham-2123 XForwardView as cDNA map |
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The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase]
C07A12.1C07A12.1cham-2123 XForwardView as cDNA map |
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The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase]
C07A12.7C07A12.7a.1C07A12.7223 XReverseView as cDNA map |
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C07A12.7C07A12.7a.2C07A12.7123 XReverseView as cDNA map |
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C07A12.7C07A12.7bC07A12.7123 XReverseView as cDNA map |
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C07A12.7C07A12.7c.1C07A12.7123 XReverseView as cDNA map |
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C07A4.3C07A4.3C07A4.3123 XForwardView as cDNA map |
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C07B5.4C07B5.4b.1C07B5.4123 XForwardView as cDNA map |
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C07B5.4C07B5.4b.2C07B5.4123 XForwardView as cDNA map |
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C08A9.3C08A9.3aC08A9.3123 XReverseView as cDNA map |
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C08A9.3C08A9.3bC08A9.3123 XReverseView as cDNA map |
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C09B8.1C09B8.1ipp-5123 XForwardView as cDNA map |
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ipp-5 encodes a type I inositol 5-phosphatase homolog. ipp-5 acts downstream of let-23 to negatively regulate IP3 signaling and is involved in spermathecal contractions during ovulation. an ipp-5::gfp transcriptional reporter is expressed in the adult distal spermatheca and weakly in the proximal sheath. [Source: WormBase]
C09B8.3C09B8.3C09B8.3123 XReverseView as cDNA map |
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C10A4.3C10A4.3C10A4.3123 XForwardView as cDNA map |
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C10A4.4C10A4.4C10A4.4223 XForwardView as cDNA map |
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C10A4.5C10A4.5C10A4.5223 XForwardView as cDNA map |
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C10A4.7C10A4.7C10A4.7223 XReverseView as cDNA map |
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C10A4.8C10A4.8mnm-2123 XReverseView as cDNA map |
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C10E2.3C10E2.3hda-4123 XForwardView as cDNA map |
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hda-4 encodes a class II histone deacetylase that contains a putative MEF-2 DNA binding domain, a nuclear localization signal domain, and a single catalytic domain and may affect locomotion, body morphology, and growth. interacts with MEF-2 in in vitro assays and is expressed in body-wall muscle, neurons, and hypodermal seam cells [Source: WormBase]
C10E2.5C10E2.5C10E2.5123 XReverseView as cDNA map |
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C11E4.3C11E4.3tag-263223 XForwardView as cDNA map |
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C11E4.6C11E4.6.1C11E4.6223 XForwardView as cDNA map |
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C11E4.6C11E4.6.2C11E4.6223 XForwardView as cDNA map |
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C11E4.7C11E4.7C11E4.7123 XForwardView as cDNA map |
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C11H1.4C11H1.4aprx-1123 XForwardView as cDNA map |
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prx-1 encodes a predicted peroxin, a subfamily 2 member of the AAA (ATPases Associated with diverse cellular Activities) family that affects growth in one large-scale RNAi screen. expressed in intestinal cells throughout development. [Source: WormBase]
C11H1.5C11H1.5C11H1.5123 XReverseView as cDNA map |
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C11H1.9C11H1.9aC11H1.9123 XReverseView as cDNA map |
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C11H1.9C11H1.9bC11H1.9123 XReverseView as cDNA map |
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C12D12.1C12D12.1aC12D12.1123 XForwardView as cDNA map |
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C12D12.1C12D12.1bC12D12.1123 XForwardView as cDNA map |
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C12D12.1C12D12.1cC12D12.1123 XForwardView as cDNA map |
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C12D12.2C12D12.2a.1glt-1123 XForwardView as cDNA map |
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glt-1 encodes a predicted plasma membrane glutamate transporter that is functional when expressed in Xenopus oocytes. expressed in the M3 pharyngeal neuron, the male tail, some anterior hypodermal cells, and in cells in the terminal bulb of the pharynx. [Source: WormBase]
C12D12.2C12D12.2a.2glt-1123 XForwardView as cDNA map |
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glt-1 encodes a predicted plasma membrane glutamate transporter that is functional when expressed in Xenopus oocytes. expressed in the M3 pharyngeal neuron, the male tail, some anterior hypodermal cells, and in cells in the terminal bulb of the pharynx. [Source: WormBase]
C13E3.1C13E3.1C13E3.1223 XForwardView as cDNA map |
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C14A11.3C14A11.3acgef-1223 XForwardView as cDNA map |
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C14A11.3C14A11.3bcgef-1123 XForwardView as cDNA map |
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C14A11.3C14A11.3ccgef-1223 XForwardView as cDNA map |
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C14A11.7C14A11.7ssr-2123 XReverseView as cDNA map |
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C14E2.2C14E2.2C14E2.2123 XReverseView as cDNA map |
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C14E2.5C14E2.5C14E2.5123 XReverseView as cDNA map |
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C14F11.4C14F11.4aC14F11.4123 XReverseView as cDNA map |
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C14F11.4C14F11.4bC14F11.4123 XReverseView as cDNA map |
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C14F11.6C14F11.6.1C14F11.6123 XReverseView as cDNA map |
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C14F11.6C14F11.6.2C14F11.6123 XReverseView as cDNA map |
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C14F5.5C14F5.5sem-5123 XReverseView as cDNA map |
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sem-5 encodes a Src homology (SH) domain 2 and 3-containing protein, orthologous to human GRB2 (OMIM:108355) and Drosophila Drk. sem-5 functions in multiple signaling pathways during development including those regulating sex myoblast migration, muscle membrane extension, vulval induction, fluid balance, viability, and formation of the male tail. SEM-5 acts downstream of the LET-23 epidermal growth factor receptor to negatively regulate RAS-, MAP-, and IP-3-, mediated signal transduction. a sem-5::yfp promoter fusion is expressed in many cells throughout development, including the hypodermis, intestine, neurons, body wall muscles, and vulval precursor cells. [Source: WormBase]
C14H10.2C14H10.2aC14H10.2123 XReverseView as cDNA map |
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We gratefully acknowledge support of this work by the William M. Keck Foundation