microRNASeq

Gene ID	Transcript ID	Common Gene Name	# of miRNA targets for specified miRNAs	Chromosome	Strand Direction	Transcript Link to view miRNA target predictions	Gene Link	Description
AC8.10	AC8.10	AC8.10	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
AC8.12	AC8.12	AC8.12	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
AC8.3	AC8.3	AC8.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
AC8.7	AC8.7	AC8.7	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
AH9.2	AH9.2	crn-4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
AH9.4	AH9.4	AH9.4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0198.2	B0198.2a	B0198.2	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0198.2	B0198.2b	B0198.2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0272.1	B0272.1	tbb-4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0302.1	B0302.1a.1	kin-25	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]
B0302.1	B0302.1a.2	kin-25	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]
B0302.1	B0302.1b	kin-25	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]
B0310.1	B0310.1b	B0310.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	B0310.1 encodes a nematode-specific transmembrane protein. loss of B0310.1 activity via RNAi results in reduced fat content in wild-type and tub-1 mutant animals, suggesting that B0301.1 plays a role in lipid metabolism. [Source: WormBase]
B0310.2	B0310.2.1	B0310.2	3	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0310.2	B0310.2.2	B0310.2	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0344.2	B0344.2	wrt-9	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	wrt-9 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of proline-rich, low-complexity sequence. the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. WRT-9 has no obvious function in RNAi assays. [Source: WormBase]
B0395.1	B0395.1	nhx-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	nhx-1 encodes a sodium/proton exchanger expressed intracellularly within hypodermal and muscle cells. NHX-1 is required for embryonic viability, and is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton. [Source: WormBase]
B0403.2	B0403.2	ubc-17	3	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0410.1	B0410.1	B0410.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0410.2	B0410.2a	vang-1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase]
B0410.2	B0410.2b	vang-1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase]
B0410.3	B0410.3	B0410.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0416.1	B0416.1	B0416.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0416.3	B0416.3	B0416.3	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0416.6	B0416.6	gly-13	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates. gly-13 is expressed throughout development in many cell types. gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14. [Source: WormBase]
B0563.1	B0563.1	B0563.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.2	B0563.2	tsp-11	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.4	B0563.4.1	tmbi-4	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.4	B0563.4.2	tmbi-4	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6a	B0563.6	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6b.1	B0563.6	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6b.2	B0563.6	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6c	B0563.6	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C01C10.1	C01C10.1	clc-2	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia. claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes. clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein. [Source: WormBase]
C01C10.2	C01C10.2b	C01C10.2	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C01C10.3	C01C10.3.1	acl-12	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C01C10.4	C01C10.4	clc-5	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	clc-5 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia. CLC-5 is worm-specific, with obvious homologs only in C. elegans. CLC-5 has no obvious function in mass RNAi assays. claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. [Source: WormBase]
C01C4.1	C01C4.1	nlp-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	nlp-1 encodes a predicted neuropeptide-like protein of the MSFamide family with similarity to Aplysia californica (sea hare) buccalin, a neuropeptide that regulates acetylcholine-induced muscle contraction. NLP-1 is expressed in the phasmid PHB tail sensory neuron, lateral neurons, head neurons, and the intestine. the precise role of NLP-1 in nervous system function and development is not yet known. [Source: WormBase]
C01C4.3	C01C4.3b	C01C4.3	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	C01C4.3 encodes a serine/threonine protein kinase. [Source: WormBase]
C02B4.1	C02B4.1	adt-1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis. [Source: WormBase]
C02B4.2	C02B4.2	nhr-17	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	nhr-17 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators. nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain. [Source: WormBase]
C02B8.5	C02B8.5	C02B8.5	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	C02B8.5 encodes a homolog of the functionally active Fmrf Receptor (FR. CG2114) of D. melanogaster. it is thus possible that C02B8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). [Source: WormBase]
C02C6.1	C02C6.1a	dyn-1	5	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase]
C02C6.1	C02C6.1b	dyn-1	6	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase]
C02C6.3	C02C6.3a	C02C6.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02C6.3	C02C6.3b	C02C6.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02D4.2	C02D4.2f	ser-2	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	ser-2 encodes at least four tyramine 7-transmembrane domain receptors (GPCRs), by alternative splicing from three different promoters, that have distinct but partially overlapping expression patterns. ser-2 has at least three alternative promoters that drive SER-2 expression in a set of sensory, inter- and motor neurons (e.g., AIY, AIZ, and RIA) adding up to ~10% of all neurons in the nervous system, as well as pharyngeal cells and head muscles. the deletion ser-2(pk1397) has no obvious mutant phenotype. LIM-4 is required for SER-2 expression, and MAB-23 is required for SER-2 expression at normally high levels. [Source: WormBase]
C02F12.10	C02F12.10	C02F12.10	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	C02F12.10 encodes a homeobox protein of uncertain affinity, but with some similarity to vertebrate Hox3 proteins and the D. melanogster homeobox protein ROUGH. C02F12.10 is expressed in a single tail neuron of hermaphrodites from late embryo to adult stages, as well as in a uterus cell separate from the vulva (perhaps in the spermetheca). C02F12.10 has no obvious function in mass RNAi assays. [Source: WormBase]
C02F12.1	C02F12.1b	tsp-17	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.3	C02F12.3.1	C02F12.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.3	C02F12.3.2	C02F12.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.3	C02F12.3.3	C02F12.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.4	C02F12.4	tag-52	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.7	C02F12.7	tag-278	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.8	C02F12.8	C02F12.8	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.9	C02F12.9	C02F12.9	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C02H7.3	C02H7.3a	aex-3	4	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	aex-3 encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584). AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively. AEX-3 is also required for egg laying and locomotion. AEX-3 is expressed in nearly all neurons. [Source: WormBase]
C03A3.1	C03A3.1a	C03A3.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03A3.1	C03A3.1b	C03A3.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03A3.3	C03A3.3	C03A3.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C03B1.2	C03B1.2	C03B1.2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03B1.5	C03B1.5	C03B1.5	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03F11.3	C03F11.3	scav-1	4	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C03G5.1	C03G5.1.1	sdha-1	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	sdha-1 is orthologous to the human gene SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT A, FLAVOPROTEIN (SDHA. OMIM:600857), which when mutated leads to complex II mitochondrial respiratory chain deficiency presenting as Leigh syndrome. [Source: WormBase]
C03G5.1	C03G5.1.2	sdha-1	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	sdha-1 is orthologous to the human gene SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT A, FLAVOPROTEIN (SDHA. OMIM:600857), which when mutated leads to complex II mitochondrial respiratory chain deficiency presenting as Leigh syndrome. [Source: WormBase]
C04A11.2	C04A11.2	C04A11.2	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C04A11.3	C04A11.3	gck-4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04A11.4	C04A11.4	adm-2	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family). like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. [Source: WormBase]
C04B4.3	C04B4.3	lips-2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04E7.1	C04E7.1	C04E7.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04E7.3	C04E7.3	C04E7.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C04E7.4	C04E7.4	C04E7.4	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C04F6.1	C04F6.1	vit-5	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	vit-5 encodes a vitellogenin, a lipid-binding protein precursor related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent. by homology, VIT-5 is predicted to function as a lipid transport protein. loss of vit-5 activity via large-scale RNA-mediated interference (RNAi) screens indicates that VIT-5 is required for embryogenesis and normal rates of postembryonic growth. VIT-5 is a major yolk component and is expressed exclusively in the adult hermaphrodite intestine from which it is secreted into the pseudocoelomic space and taken up by oocytes. [Source: WormBase]
C04F6.5	C04F6.5	dhs-27	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	dhs-27 encodes a short-chain dehydrogenase predicted to be mitochondrial. [Source: WormBase]
C05A9.1	C05A9.1a	pgp-5	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily. by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins. however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. [Source: WormBase]
C05A9.1	C05A9.1b	pgp-5	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily. by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins. however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. [Source: WormBase]
C05C9.1	C05C9.1	C05C9.1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C05C9.3	C05C9.3	C05C9.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). [Source: WormBase]
C05D9.1	C05D9.1.1	snx-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C05D9.1	C05D9.1.2	snx-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C05D9.7	C05D9.7	C05D9.7	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C05E11.1	C05E11.1.1	lnp-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	lnp-1 encodes a highly conserved protein of unknown function, orthologous to human LUNAPARK/KIAA1715 (OMIM:610236), that is required for normally short body length, normal locomotion, fat content, acetylcholine neurotransmission, localization of RAB-3 and SNB-1, and sensitivity to aldicarb. LNP-1 is expressed in muscles, hypodermal cells, and neurons. within neurons, LNP-1 is localized to cell bodies, neuritic processes and commissures, and requiring UNC-104 for localization outside of cell bodies. LNP-1 is likely to act presynaptically. LNP-1 contains two N-terminal predicted transmembrane sequences, and an atypical zinc finger domain (C2HC2). [Source: WormBase]
C05E11.4	C05E11.4	amt-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	amt-1 encodes a transmembrane transporter that by homology, is predicted to transport ammonium ions across the plasma membrane. as loss of amt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of AMT-1 in C. elegans development and/or behavior is not yet known. [Source: WormBase]
C05E11.5	C05E11.5	amt-4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	amt-4 encodes a member of the ammonium transporter protein family. [Source: WormBase]
C05E11.7	C05E11.7	C05E11.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C05E7.2	C05E7.2	C05E7.2	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C05E7.4	C05E7.4	C05E7.4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C05G5.1	C05G5.1	C05G5.1	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C06E2.5	C06E2.5.1	C06E2.5	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C06E2.5	C06E2.5.2	C06E2.5	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C06E2.8	C06E2.8	ins-9	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	ins-9 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440). INS-9 is one of 38 insulin-like peptides in C. elegans and although INS-9 overexpression can result in low levels of embryonic and larval lethality, the precise role of INS-9 in C. elegans development is not yet clear. INS-9 is expressed exclusively in the amphid sensory neurons ASI and ASJ that regulate dauer arrest, but INS-9 overexpression does not enhance dauer arrest in a wild-type or daf-2 mutant background. [Source: WormBase]
C06G1.1	C06G1.1a	C06G1.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C06G1.1	C06G1.1b	C06G1.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C06G1.4	C06G1.4.1	ain-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]
C06G1.4	C06G1.4.2	ain-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]
C06G1.6	C06G1.6	C06G1.6	3	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C07A12.1	C07A12.1a	ham-2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase]
C07A12.1	C07A12.1b	ham-2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase]
C07A12.1	C07A12.1c	ham-2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase]
C07A12.2	C07A12.2	C07A12.2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl

Gene ID

Transcript ID

Common Gene Name

# of miRNA targets
for specified miRNAs

Chromosome

Strand Direction

Transcript Link to view miRNA target predictions

Gene Link

Description

AC8.10

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

AC8.12

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

AC8.3

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

AC8.7

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

AH9.2

crn-4

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

AH9.4

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

B0198.2

B0198.2a

B0198.2

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

B0198.2

B0198.2b

B0198.2

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

B0272.1

tbb-4

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

B0302.1

B0302.1a.1

kin-25

23 X

Forward

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Internal |
Ensembl

kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]

B0302.1

B0302.1a.2

kin-25

23 X

Forward

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View as Table

Internal |
Ensembl

kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]

B0302.1

B0302.1b

kin-25

23 X

Forward

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View as Table

Internal |
Ensembl

kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]

B0310.1

B0310.1b

B0310.1

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

B0310.1 encodes a nematode-specific transmembrane protein. loss of B0310.1 activity via RNAi results in reduced fat content in wild-type and tub-1 mutant animals, suggesting that B0301.1 plays a role in lipid metabolism. [Source: WormBase]

B0310.2

B0310.2.1

B0310.2

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

B0310.2

B0310.2.2

B0310.2

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

B0344.2

wrt-9

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

wrt-9 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of proline-rich, low-complexity sequence. the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins. WRT-9 has no obvious function in RNAi assays. [Source: WormBase]

B0395.1

nhx-1

23 X

Forward

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Internal |
Ensembl

nhx-1 encodes a sodium/proton exchanger expressed intracellularly within hypodermal and muscle cells. NHX-1 is required for embryonic viability, and is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton. [Source: WormBase]

B0403.2

ubc-17

23 X

Forward

View as cDNA map |
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Internal |
Ensembl

B0410.1

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

B0410.2

B0410.2a

vang-1

23 X

Forward

View as cDNA map |
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Internal |
Ensembl

vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase]

B0410.2

B0410.2b

vang-1

23 X

Forward

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Ensembl

B0410.3

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

B0416.1

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

B0416.3

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

B0416.6

gly-13

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates. gly-13 is expressed throughout development in many cell types. gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14. [Source: WormBase]

B0563.1

23 X

Forward

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Internal |
Ensembl

B0563.2

tsp-11

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

B0563.4

B0563.4.1

tmbi-4

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

B0563.4

B0563.4.2

tmbi-4

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

B0563.6

B0563.6a

B0563.6

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

B0563.6

B0563.6b.1

B0563.6

23 X

Forward

View as cDNA map |
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Internal |
Ensembl

B0563.6

B0563.6b.2

B0563.6

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

B0563.6

B0563.6c

B0563.6

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

C01C10.1

clc-2

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia. claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes. clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein. [Source: WormBase]

C01C10.2

C01C10.2b

C01C10.2

23 X

Reverse

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Internal |
Ensembl

C01C10.3

C01C10.3.1

acl-12

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

C01C10.4

clc-5

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

clc-5 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia. CLC-5 is worm-specific, with obvious homologs only in C. elegans. CLC-5 has no obvious function in mass RNAi assays. claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. [Source: WormBase]

C01C4.1

nlp-1

23 X

Forward

View as cDNA map |
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Internal |
Ensembl

nlp-1 encodes a predicted neuropeptide-like protein of the MSFamide family with similarity to Aplysia californica (sea hare) buccalin, a neuropeptide that regulates acetylcholine-induced muscle contraction. NLP-1 is expressed in the phasmid PHB tail sensory neuron, lateral neurons, head neurons, and the intestine. the precise role of NLP-1 in nervous system function and development is not yet known. [Source: WormBase]

C01C4.3

C01C4.3b

C01C4.3

23 X

Forward

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Internal |
Ensembl

C01C4.3 encodes a serine/threonine protein kinase. [Source: WormBase]

C02B4.1

adt-1

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis. [Source: WormBase]

C02B4.2

nhr-17

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

nhr-17 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators. nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain. [Source: WormBase]

C02B8.5

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

C02B8.5 encodes a homolog of the functionally active Fmrf Receptor (FR. CG2114) of D. melanogaster. it is thus possible that C02B8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). [Source: WormBase]

C02C6.1

C02C6.1a

dyn-1

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase]

C02C6.1

C02C6.1b

dyn-1

23 X

Forward

View as cDNA map |
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Internal |
Ensembl

C02C6.3

C02C6.3a

C02C6.3

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

C02C6.3

C02C6.3b

C02C6.3

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

C02D4.2

C02D4.2f

ser-2

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

ser-2 encodes at least four tyramine 7-transmembrane domain receptors (GPCRs), by alternative splicing from three different promoters, that have distinct but partially overlapping expression patterns. ser-2 has at least three alternative promoters that drive SER-2 expression in a set of sensory, inter- and motor neurons (e.g., AIY, AIZ, and RIA) adding up to ~10% of all neurons in the nervous system, as well as pharyngeal cells and head muscles. the deletion ser-2(pk1397) has no obvious mutant phenotype. LIM-4 is required for SER-2 expression, and MAB-23 is required for SER-2 expression at normally high levels. [Source: WormBase]

C02F12.10

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

C02F12.10 encodes a homeobox protein of uncertain affinity, but with some similarity to vertebrate Hox3 proteins and the D. melanogster homeobox protein ROUGH. C02F12.10 is expressed in a single tail neuron of hermaphrodites from late embryo to adult stages, as well as in a uterus cell separate from the vulva (perhaps in the spermetheca). C02F12.10 has no obvious function in mass RNAi assays. [Source: WormBase]

C02F12.1

C02F12.1b

tsp-17

23 X

Forward

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Internal |
Ensembl

C02F12.3

C02F12.3.1

C02F12.3

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

C02F12.3

C02F12.3.2

C02F12.3

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

C02F12.3

C02F12.3.3

C02F12.3

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

C02F12.4

tag-52

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

C02F12.7

tag-278

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

C02F12.8

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

C02F12.9

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

C02H7.3

C02H7.3a

aex-3

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

aex-3 encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584). AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively. AEX-3 is also required for egg laying and locomotion. AEX-3 is expressed in nearly all neurons. [Source: WormBase]

C03A3.1

C03A3.1a

C03A3.1

23 X

Forward

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Internal |
Ensembl

C03A3.1

C03A3.1b

C03A3.1

23 X

Forward

View as cDNA map |
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Internal |
Ensembl

C03A3.3

23 X

Reverse

View as cDNA map |
View as Table

Internal |
Ensembl

C03B1.2

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

C03B1.5

23 X

Forward

View as cDNA map |
View as Table

Internal |
Ensembl

C03F11.3

scav-1

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

C03G5.1

C03G5.1.1

sdha-1

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

sdha-1 is orthologous to the human gene SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT A, FLAVOPROTEIN (SDHA. OMIM:600857), which when mutated leads to complex II mitochondrial respiratory chain deficiency presenting as Leigh syndrome. [Source: WormBase]

C03G5.1

C03G5.1.2

sdha-1

23 X

Reverse

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Ensembl

C04A11.2

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

C04A11.3

gck-4

23 X

Forward

View as cDNA map |
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Internal |
Ensembl

C04A11.4

adm-2

23 X

Forward

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Internal |
Ensembl

adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family). like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. [Source: WormBase]

C04B4.3

lips-2

23 X

Forward

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Ensembl

C04E7.1

23 X

Forward

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Ensembl

C04E7.3

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

C04E7.4

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

C04F6.1

vit-5

23 X

Forward

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Internal |
Ensembl

vit-5 encodes a vitellogenin, a lipid-binding protein precursor related to vertebrate vitellogenins and mammalian ApoB-100, a core LDL particle constituent. by homology, VIT-5 is predicted to function as a lipid transport protein. loss of vit-5 activity via large-scale RNA-mediated interference (RNAi) screens indicates that VIT-5 is required for embryogenesis and normal rates of postembryonic growth. VIT-5 is a major yolk component and is expressed exclusively in the adult hermaphrodite intestine from which it is secreted into the pseudocoelomic space and taken up by oocytes. [Source: WormBase]

C04F6.5

dhs-27

23 X

Reverse

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Ensembl

dhs-27 encodes a short-chain dehydrogenase predicted to be mitochondrial. [Source: WormBase]

C05A9.1

C05A9.1a

pgp-5

23 X

Reverse

View as cDNA map |
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Internal |
Ensembl

pgp-5 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily. by homology, PGP-5 is predicted to function as an ATP-dependent efflux pump that protects C. elegans by exporting exogenous toxins. however, as loss of pgp-5 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of PGP-5 in C. elegans development and/or behavior is not yet known. [Source: WormBase]

C05A9.1

C05A9.1b

pgp-5

23 X

Reverse

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Ensembl

C05C9.1

23 X

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Ensembl

C05C9.3

23 X

Reverse

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Ensembl

The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). [Source: WormBase]

C05D9.1

C05D9.1.1

snx-1

23 X

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C05D9.1

C05D9.1.2

snx-1

23 X

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C05D9.7

23 X

Reverse

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Ensembl

C05E11.1

C05E11.1.1

lnp-1

23 X

Forward

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Ensembl

lnp-1 encodes a highly conserved protein of unknown function, orthologous to human LUNAPARK/KIAA1715 (OMIM:610236), that is required for normally short body length, normal locomotion, fat content, acetylcholine neurotransmission, localization of RAB-3 and SNB-1, and sensitivity to aldicarb. LNP-1 is expressed in muscles, hypodermal cells, and neurons. within neurons, LNP-1 is localized to cell bodies, neuritic processes and commissures, and requiring UNC-104 for localization outside of cell bodies. LNP-1 is likely to act presynaptically. LNP-1 contains two N-terminal predicted transmembrane sequences, and an atypical zinc finger domain (C2HC2). [Source: WormBase]

C05E11.4

amt-1

23 X

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amt-1 encodes a transmembrane transporter that by homology, is predicted to transport ammonium ions across the plasma membrane. as loss of amt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of AMT-1 in C. elegans development and/or behavior is not yet known. [Source: WormBase]

C05E11.5

amt-4

23 X

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amt-4 encodes a member of the ammonium transporter protein family. [Source: WormBase]

C05E11.7

23 X

Reverse

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Ensembl

C05E7.2

23 X

Reverse

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Ensembl

C05E7.4

23 X

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C05G5.1

23 X

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C06E2.5

C06E2.5.1

C06E2.5

23 X

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C06E2.5

C06E2.5.2

C06E2.5

23 X

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C06E2.8

ins-9

23 X

Reverse

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ins-9 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440). INS-9 is one of 38 insulin-like peptides in C. elegans and although INS-9 overexpression can result in low levels of embryonic and larval lethality, the precise role of INS-9 in C. elegans development is not yet clear. INS-9 is expressed exclusively in the amphid sensory neurons ASI and ASJ that regulate dauer arrest, but INS-9 overexpression does not enhance dauer arrest in a wild-type or daf-2 mutant background. [Source: WormBase]

C06G1.1

C06G1.1a

C06G1.1

23 X

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C06G1.1

C06G1.1b

C06G1.1

23 X

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C06G1.4

C06G1.4.1

ain-1

23 X

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ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]

C06G1.4

C06G1.4.2

ain-1

23 X

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C06G1.6

23 X

Reverse

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C07A12.1

C07A12.1a

ham-2

23 X

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The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase]

C07A12.1

C07A12.1b

ham-2

23 X

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C07A12.1

C07A12.1c

ham-2

23 X

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