| Gene ID | Transcript ID | Common Gene Name | # of miRNA targets for specified miRNAs | Chromosome | Strand Direction | Transcript Link to view miRNA target predictions | Gene Link | Description |
|---|---|---|---|---|---|---|---|---|
| B0198.3 | B0198.3a | B0198.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| B0302.1 | B0302.1a.1 | kin-25 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase] |
| B0302.1 | B0302.1a.2 | kin-25 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase] |
| B0302.1 | B0302.1b | kin-25 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase] |
| B0403.5 | B0403.5 | B0403.5 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| B0563.2 | B0563.2 | tsp-11 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C01C10.3 | C01C10.3.1 | acl-12 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C01C10.3 | C01C10.3.2 | acl-12 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C02B4.1 | C02B4.1 | adt-1 | 3 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis. [Source: WormBase] |
| C02B4.2 | C02B4.2 | nhr-17 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | nhr-17 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators. nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain. [Source: WormBase] |
| C02C6.1 | C02C6.1a | dyn-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase] |
| C02C6.1 | C02C6.1b | dyn-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase] |
| C02C6.3 | C02C6.3a | C02C6.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C02C6.3 | C02C6.3b | C02C6.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C02C6.3 | C02C6.3c | C02C6.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C02C6.3 | C02C6.3d.1 | C02C6.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C02F12.1 | C02F12.1a | tsp-17 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C02F12.1 | C02F12.1b | tsp-17 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C02F12.7 | C02F12.7 | tag-278 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C03A3.2 | C03A3.2.1 | C03A3.2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C03A3.2 | C03A3.2.2 | C03A3.2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C03B1.12 | C03B1.12.1 | lmp-1 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | lmp-1 encodes a protein with similarity to vertebrate lysosome-associated membrane proteins CD68, and appears to be the only protein in C. elegans that has a GYXX (phi) vertebrate lysosomal targeting sequence at its carboxy terminus. localized to the periphery of a large population of membrane bound organelles (granules) seen throughout the early embryos and restricted to the cells of the intestine during later stages. [Source: WormBase] |
| C03B1.12 | C03B1.12.2 | lmp-1 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | lmp-1 encodes a protein with similarity to vertebrate lysosome-associated membrane proteins CD68, and appears to be the only protein in C. elegans that has a GYXX (phi) vertebrate lysosomal targeting sequence at its carboxy terminus. localized to the periphery of a large population of membrane bound organelles (granules) seen throughout the early embryos and restricted to the cells of the intestine during later stages. [Source: WormBase] |
| C03F11.3 | C03F11.3 | scav-1 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C03H12.1 | C03H12.1 | C03H12.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C04A11.5 | C04A11.5.1 | C04A11.5 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C04A11.5 | C04A11.5.2 | C04A11.5 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C04E7.1 | C04E7.1 | C04E7.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C05D9.1 | C05D9.1.1 | snx-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C05D9.1 | C05D9.1.2 | snx-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C05D9.1 | C05D9.1.3 | snx-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C05D9.2 | C05D9.2.1 | lmp-2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase] |
| C05D9.2 | C05D9.2.2 | lmp-2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase] |
| C05D9.2 | C05D9.2.3 | lmp-2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | lmp-2 encodes a transmembrane protein that is one of two C. elegans LAMP (lysosomal associated membrane glycoprotein) homologs. [Source: WormBase] |
| C05D9.3 | C05D9.3 | C05D9.3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C05E11.4 | C05E11.4 | amt-1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | amt-1 encodes a transmembrane transporter that by homology, is predicted to transport ammonium ions across the plasma membrane. as loss of amt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of AMT-1 in C. elegans development and/or behavior is not yet known. [Source: WormBase] |
| C05E11.7 | C05E11.7 | C05E11.7 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C05E7.1 | C05E7.1 | C05E7.1 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C06E2.7 | C06E2.7 | ubc-22 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | ubc-22 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae UBC8 and human UBC1/HIP2 (Huntingtin interacting protein 2, OMIM:602846) which are involved in regulating fructose-1,6-bisphosphatase and huntingtin catabolism, respectively. by homology, UBC-22 is likely required for covalent attachment of ubiquitin to select target proteins to facilitate their degradation. however, as loss of UBC-22 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UBC-22 in C. elegans development and/or behavior is not yet known. [Source: WormBase] |
| C06G1.1 | C06G1.1a | C06G1.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C06G1.1 | C06G1.1b | C06G1.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C06G1.4 | C06G1.4.1 | ain-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase] |
| C06G1.4 | C06G1.4.2 | ain-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase] |
| C06G1.6 | C06G1.6 | C06G1.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C07A4.3 | C07A4.3 | C07A4.3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C07B5.3 | C07B5.3 | C07B5.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C07D8.6 | C07D8.6 | C07D8.6 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C08A9.7 | C08A9.7 | sdz-2 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C09B7.1 | C09B7.1a | ser-7 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ser-7 encodes an ortholog of mammalian 5-HT7 metabotropic serotonin receptors. SER-7 is required for stimulation of egg-laying or pharyngeal pumping by serotonin (5-HT), for regular pumping in response to bacteria, and probably also for 5-HT to activate MC neurons. SER-7 and SER-1 are redundantly required for normal egg-laying. SER-7 is expressed in head and tail neurons, pharyngeal neurons (M4, MCs, I2s, I3, M5, M3s, I4, I6, and M2s), vulval muscles, and intestine. heterologously expressed SER-7, when challenged with 5-HT, stimulates intracellular adenylate cyclase activity. SER-7 has high affinity for 5-HT and tryptamine, but not for 5-CT, and is unaffected by at least some agonists of mammalian 5-HT7 receptors. [Source: WormBase] |
| C09B7.1 | C09B7.1b | ser-7 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ser-7 encodes an ortholog of mammalian 5-HT7 metabotropic serotonin receptors. SER-7 is required for stimulation of egg-laying or pharyngeal pumping by serotonin (5-HT), for regular pumping in response to bacteria, and probably also for 5-HT to activate MC neurons. SER-7 and SER-1 are redundantly required for normal egg-laying. SER-7 is expressed in head and tail neurons, pharyngeal neurons (M4, MCs, I2s, I3, M5, M3s, I4, I6, and M2s), vulval muscles, and intestine. heterologously expressed SER-7, when challenged with 5-HT, stimulates intracellular adenylate cyclase activity. SER-7 has high affinity for 5-HT and tryptamine, but not for 5-CT, and is unaffected by at least some agonists of mammalian 5-HT7 receptors. [Source: WormBase] |
| C09C7.1 | C09C7.1 | zig-4 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | zig-4 encodes a predicted secreted protein that is a member of the immunoglobulin superfamily of proteins. ZIG-4 activity is required for maintenance of ventral nerve cord organization: the AVKL/R and PVQL/R axons of the left and right ventral nerve cords do not maintain their proper spatial positions and drift into the opposite cord. a zig-4::gfp reporter fusion is expressed in the PVT, ASK, BAG, and M2 neurons, with expression also seen during the L1 stage in pharyngeal mesoderm and ectoderm. [Source: WormBase] |
| C11E4.8 | C11E4.8 | C11E4.8 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C11H1.4 | C11H1.4a | prx-1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | prx-1 encodes a predicted peroxin, a subfamily 2 member of the AAA (ATPases Associated with diverse cellular Activities) family that affects growth in one large-scale RNAi screen. expressed in intestinal cells throughout development. [Source: WormBase] |
| C12D12.1 | C12D12.1a | C12D12.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C12D12.1 | C12D12.1b | C12D12.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C12D12.1 | C12D12.1c | C12D12.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C13E3.1 | C13E3.1 | C13E3.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C14A11.7 | C14A11.7 | ssr-2 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C15A7.2 | C15A7.2 | C15A7.2 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C15H9.1 | C15H9.1 | nnt-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | nnt-1 encodes a proton-pumping nicotinamide nucleotide transhydrogenase predicted to be mitochondrial. [Source: WormBase] |
| C15H9.3 | C15H9.3 | C15H9.3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C17G1.6 | C17G1.6a | nas-37 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | nas-37 encodes a Astacin-class metalloprotease required for full ecdysis that is expressed in hypodermal cells 4 hours before each ecdysis. NAS-37 protein has an N-terminal signal sequence followed by an Astacin protease domain and three protein-binding domains (EGF-like, CUB, and thrombospondin). NAS-37 accumulates in anterior cuticle, being shed with it after ecdysis. nas-37 mutants fail to complete anterior ecdysis at each molt. nas-37(ox196) mutations alter an evolutionarily invariant histidine residue yet are phenotypically indistinguishable from null mutations, consistent with the hypothesis that NAS-37 encodes a functional protease. NAS-37 orthologs are found in other nematodes such as Brugia malayi. [Source: WormBase] |
| C17H11.6 | C17H11.6a | C17H11.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17H11.6 | C17H11.6b | C17H11.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17H11.6 | C17H11.6c.1 | C17H11.6 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17H11.6 | C17H11.6c.2 | C17H11.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17H11.6 | C17H11.6c.3 | C17H11.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C17H11.6 | C17H11.6d | C17H11.6 | 2 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C18B2.1 | C18B2.1 | C18B2.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C18B2.6 | C18B2.6 | C18B2.6 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C23F12.1 | C23F12.1a | fln-2 | 3 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C23F12.1 | C23F12.1c | fln-2 | 3 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C23F12.1 | C23F12.1d | fln-2 | 3 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C23H4.3 | C23H4.3 | C23H4.3 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C23H4.7 | C23H4.7 | C23H4.7 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C24A3.1 | C24A3.1 | C24A3.1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C24A3.6 | C24A3.6.1 | twk-18 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | twk-18 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains. TWK-18 was originally defined by gain-of-function mutations that result in embryonic lethality at the two-fold stage, locomotion defects, longer than normal body length, abnormal egg-laying, and temperature-sensitive paralysis. as loss of TWK-18 function via reversion or RNA-mediated interference does not result in any abnormalities, TWK-18 likely functions redundantly with other TWK channels. TWK-18 can function as an outwardly rectifying K+ channel, and is activated by temperature increases, thus making it a temperature-gated channel. TWK-18 is expressed in body wall muscle. [Source: WormBase] |
| C24A3.6 | C24A3.6.2 | twk-18 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | twk-18 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains. TWK-18 was originally defined by gain-of-function mutations that result in embryonic lethality at the two-fold stage, locomotion defects, longer than normal body length, abnormal egg-laying, and temperature-sensitive paralysis. as loss of TWK-18 function via reversion or RNA-mediated interference does not result in any abnormalities, TWK-18 likely functions redundantly with other TWK channels. TWK-18 can function as an outwardly rectifying K+ channel, and is activated by temperature increases, thus making it a temperature-gated channel. TWK-18 is expressed in body wall muscle. [Source: WormBase] |
| C24A3.6 | C24A3.6.3 | twk-18 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | twk-18 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains. TWK-18 was originally defined by gain-of-function mutations that result in embryonic lethality at the two-fold stage, locomotion defects, longer than normal body length, abnormal egg-laying, and temperature-sensitive paralysis. as loss of TWK-18 function via reversion or RNA-mediated interference does not result in any abnormalities, TWK-18 likely functions redundantly with other TWK channels. TWK-18 can function as an outwardly rectifying K+ channel, and is activated by temperature increases, thus making it a temperature-gated channel. TWK-18 is expressed in body wall muscle. [Source: WormBase] |
| C24A8.3 | C24A8.3 | pqn-15 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). [Source: WormBase] |
| C25A11.4 | C25A11.4a | ajm-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo. AJM-1 contains a coiled-coil motif. AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo. AJM-1 is mislocalized in a dlg-1(RNAi) background. LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia. CLC-1 colocalizes with AJM-1. vab-9 mutations enhance the adhesion defects of ajm-1 mutants. ajm-1 is expressed at the apical borders of all epithelia. [Source: WormBase] |
| C25A11.4 | C25A11.4d | ajm-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo. AJM-1 contains a coiled-coil motif. AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo. AJM-1 is mislocalized in a dlg-1(RNAi) background. LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia. CLC-1 colocalizes with AJM-1. vab-9 mutations enhance the adhesion defects of ajm-1 mutants. ajm-1 is expressed at the apical borders of all epithelia. [Source: WormBase] |
| C25B8.3 | C25B8.3a | cpr-6 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C25B8.3 | C25B8.3b | cpr-6 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C25B8.3 | C25B8.3c | cpr-6 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C25F6.3 | C25F6.3 | dpyd-1 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | dpyd-1 encodes the C. elegans ortholog of human DihydroPYrimidine Dehydrogenase (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270). DPYD-1 is the first and rate-limiting enzyme for uracil and thymine metabolism to 5,6-dihydrouracil and 5,6-dihydrothymine, respectively, and in humans, functions in metabolism of the anti-cancer pyrimidine antagonist 5-fluorouracil (5-FU). in C. elegans, loss of dpyd-1 activity via RNAi results in sensitivity (decreased survival) to 5-FU while conversely, DPYD-1 overexpression affords increased germ cell survivability to 5-FU. [Source: WormBase] |
| C25F6.4 | C25F6.4 | ddr-1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | The C25F6.4 gene encodes a protein tyrosine kinase homolog that is also homologous to human RS1. [Source: WormBase] |
| C25G6.1 | C25G6.1 | C25G6.1 | 2 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C26B9.7 | C26B9.7 | C26B9.7 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C27C12.3 | C27C12.3 | C27C12.3 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | C27C12.3 encodes a novel protein that is conserved in C. elegans. three other genes related to C27C12.3 are present in tandem on the X chromosome. in situ hybridization studies indicate that C27C12.3 mRNA is expressed in the proximal germline. [Source: WormBase] |
| C27C12.6 | C27C12.6 | dmd-4 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C27C12.7 | C27C12.7 | dpf-2 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C28G1.1 | C28G1.1.1 | ubc-23 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ubc-23 encodes a predicted conjugating enzyme (UBCs/E2s) of the ubiquitin-conjugation system. expressed in larvae and adults in cells around the pharynx and in intestinal cells. [Source: WormBase] |
| C28G1.1 | C28G1.1.2 | ubc-23 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | ubc-23 encodes a predicted conjugating enzyme (UBCs/E2s) of the ubiquitin-conjugation system. expressed in larvae and adults in cells around the pharynx and in intestinal cells. [Source: WormBase] |
| C28G1.3 | C28G1.3 | sec-15 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C28G1.4 | C28G1.4 | C28G1.4 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C29F7.1 | C29F7.1 | C29F7.1 | 3 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C30F2.2 | C30F2.2 | C30F2.2 | 1 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | |
| C31E10.6 | C31E10.6 | C31E10.6 | 1 | 23 X | Forward | View as cDNA map | View as Table | Internal | Ensembl | |
| C31H2.2 | C31H2.2 | dpy-8 | 3 | 23 X | Reverse | View as cDNA map | View as Table | Internal | Ensembl | dpy-8 encodes a collagen with a nematode-specific N-terminal domain that is required for normal body morphology and (perhaps) for a normal embryonic cell division rate. dpy-8 interacts genetically with emb-5 and glp-1. [Source: WormBase] |