microRNASeq

Gene ID	Transcript ID	Common Gene Name	# of miRNA targets for specified miRNAs	Chromosome	Strand Direction	Transcript Link to view miRNA target predictions	Gene Link	Description
AC8.10	AC8.10	AC8.10	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
AC8.3	AC8.3	AC8.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0198.3	B0198.3a	B0198.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0272.1	B0272.1	tbb-4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0272.2	B0272.2	memb-1	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0272.4	B0272.4	B0272.4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0302.1	B0302.1a.1	kin-25	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]
B0302.1	B0302.1a.2	kin-25	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]
B0302.1	B0302.1b	kin-25	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]
B0310.3	B0310.3	B0310.3	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0395.2	B0395.2	mboa-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	mboa-1 encodes a putative acyl-Coenzyme A:cholesterol ('sterol') O-acyltransferase, orthologous to human SOAT1 (OMIM:102642). MBOA-1 is required for normal locomotion and normally long lifespan in mass RNAi assays. mboa-1 is expressed in the seam cells and nervous systems of larvae and adults, and in the adult reproductive system. [Source: WormBase]
B0403.2	B0403.2	ubc-17	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0403.5	B0403.5	B0403.5	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0410.2	B0410.2a	vang-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase]
B0410.2	B0410.2b	vang-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase]
B0416.1	B0416.1	B0416.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0416.4	B0416.4	B0416.4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0416.6	B0416.6	gly-13	3	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates. gly-13 is expressed throughout development in many cell types. gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14. [Source: WormBase]
B0563.10	B0563.10	B0563.10	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6a	B0563.6	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6b.1	B0563.6	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6b.2	B0563.6	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
B0563.6	B0563.6c	B0563.6	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C01C4.3	C01C4.3b	C01C4.3	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	C01C4.3 encodes a serine/threonine protein kinase. [Source: WormBase]
C02B4.1	C02B4.1	adt-1	4	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis. [Source: WormBase]
C02B8.1	C02B8.1.1	C02B8.1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C02B8.1	C02B8.1.2	C02B8.1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C02B8.5	C02B8.5	C02B8.5	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	C02B8.5 encodes a homolog of the functionally active Fmrf Receptor (FR. CG2114) of D. melanogaster. it is thus possible that C02B8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). [Source: WormBase]
C02C6.2	C02C6.2a	olrn-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	olrn-1 encodes, by alternative splicing, two isoforms of a transmembrane protein required for differentiation of the AWC[ON] neuron, expression of str-2 in AWC[ON], adaptation to benzaldehyde, chemotaxis to butanone, and enhancement of chemotaxis to butanone by the presence of food. OLRN-1 is orthologous to Drosophila melanogaster RAW and Schistosoma japonicum SJCHGC05616. while OLRN-1 has orthologs in nematodes, trematodes, and arthropods, its has no obvious chordate homologs. OLRN-6 is expressed in many pharyngeal neurons and some head neurons, but is required solely in the AWC[ON] neuron for butanone enhancement. OLRN-6's function in butanone enhancement is both serotonin- and dopamine-independent, and appears to also act in chemotactic enhancement of 2,3-pentanedione and isoamyl alcohol. by orthology with RAW, OLRN-6 is predicted to inhibit JNK-1 signalling, which may in turn allow the asymmetrical AWC[ON] fate to emerge. [Source: WormBase]
C02C6.2	C02C6.2b	olrn-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	olrn-1 encodes, by alternative splicing, two isoforms of a transmembrane protein required for differentiation of the AWC[ON] neuron, expression of str-2 in AWC[ON], adaptation to benzaldehyde, chemotaxis to butanone, and enhancement of chemotaxis to butanone by the presence of food. OLRN-1 is orthologous to Drosophila melanogaster RAW and Schistosoma japonicum SJCHGC05616. while OLRN-1 has orthologs in nematodes, trematodes, and arthropods, its has no obvious chordate homologs. OLRN-6 is expressed in many pharyngeal neurons and some head neurons, but is required solely in the AWC[ON] neuron for butanone enhancement. OLRN-6's function in butanone enhancement is both serotonin- and dopamine-independent, and appears to also act in chemotactic enhancement of 2,3-pentanedione and isoamyl alcohol. by orthology with RAW, OLRN-6 is predicted to inhibit JNK-1 signalling, which may in turn allow the asymmetrical AWC[ON] fate to emerge. [Source: WormBase]
C02C6.3	C02C6.3a	C02C6.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02D4.1	C02D4.1	jud-4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	jud-4 encodes an unfamiliar protein, putatively secreted, that is required both for normal sensitivity to ethanol and for survival after freezing and thawing. JUD-4 is expressed in hypodermis and vulval muscles. JUD-4 is orthologous to Brugia malayi Bm1_40315, but lacks obvious orthologies to non-nematode proteins. JUD-4's C-terminal domain has possible similarity to F40E10.5, and to proteins such as human HOMER1. jud-4(ys18) mutants show delayed sensitivity to ethanol levels that rapidly paralyze normal worms, but do not survive freezing and rethawing as does wild-type. JUD-4 has no obvious function in mass RNAi assays. [Source: WormBase]
C02F12.1	C02F12.1b	tsp-17	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.4	C02F12.4	tag-52	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02F12.8	C02F12.8	C02F12.8	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C02H7.1	C02H7.1	dyf-11	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	dyf-11 encodes a conserved protein orthologous to the human microtubule-binding protein MIP-T3 and that contains a lysine-rich region and a C-terminal coiled-coil domain present in a number of intraflagellar transport (IFT) complex B proteins. DYF-11 activity is required continuously in sensory neurons for formation of medial and distal ciliary segments and thus, for normal sensory cilium morphology and function and chemotaxis. a dyf-11::gfp promoter fusion is expressed in all ciliated sensory neurons as well as in the AQR, PQR, ADE, and PDR neurons. a DYF-11::GFP protein fusion is detected throughout the cilium and appears to localize to IFT-B particles in a manner consistent with an early role in IFT-B particle assembly. dyf-11 expression in ciliated neurons is dependent upon the presence of the DAF-19 RFX transcription factor. [Source: WormBase]
C02H7.3	C02H7.3a	aex-3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	aex-3 encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584). AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively. AEX-3 is also required for egg laying and locomotion. AEX-3 is expressed in nearly all neurons. [Source: WormBase]
C03B1.4	C03B1.4	C03B1.4	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03B1.7	C03B1.7	C03B1.7	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03B1.9	C03B1.9	C03B1.9	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C03F11.1	C03F11.1	C03F11.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C03F11.4	C03F11.4.1	C03F11.4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C03F11.4	C03F11.4.2	C03F11.4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C03F11.4	C03F11.4.3	C03F11.4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C03H12.1	C03H12.1	C03H12.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04A11.1	C04A11.1	C04A11.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04A11.3	C04A11.3	gck-4	3	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C04A11.4	C04A11.4	adm-2	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family). like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. [Source: WormBase]
C04C11.1	C04C11.1a	C04C11.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C05A9.2	C05A9.2	C05A9.2	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C05C9.3	C05C9.3	C05C9.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). [Source: WormBase]
C05E11.7	C05E11.7	C05E11.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C05E7.2	C05E7.2	C05E7.2	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C05E7.3	C05E7.3	C05E7.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C05G5.1	C05G5.1	C05G5.1	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C05G5.5	C05G5.5	C05G5.5	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C06G1.2	C06G1.2	C06G1.2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C06G1.4	C06G1.4.1	ain-1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]
C06G1.4	C06G1.4.2	ain-1	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]
C07A12.1	C07A12.1a	ham-2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase]
C07A12.1	C07A12.1b	ham-2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase]
C07A12.1	C07A12.1c	ham-2	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase]
C07A12.3	C07A12.3a	nhr-35	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C07A12.5	C07A12.5a	spr-3	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C07A12.7	C07A12.7a.1	C07A12.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C07A12.7	C07A12.7a.2	C07A12.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C07A12.7	C07A12.7b	C07A12.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C07A12.7	C07A12.7c.1	C07A12.7	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C07A4.1	C07A4.1	tiar-3	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C07B5.4	C07B5.4a.1	C07B5.4	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C07B5.4	C07B5.4a.2	C07B5.4	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C07B5.4	C07B5.4b.1	C07B5.4	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C07B5.4	C07B5.4b.2	C07B5.4	2	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C08A9.1	C08A9.1	sod-3	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan. sod-3 mRNA levels are diminished by mutation of daf-16 and chromatin immunoprecipitation (ChIP) studies demonstrate that DAF-16 can directly bind the sod-3 promoter. heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress. [Source: WormBase]
C08A9.6	C08A9.6	C08A9.6	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C09B8.1	C09B8.1	ipp-5	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	ipp-5 encodes a type I inositol 5-phosphatase homolog. ipp-5 acts downstream of let-23 to negatively regulate IP3 signaling and is involved in spermathecal contractions during ovulation. an ipp-5::gfp transcriptional reporter is expressed in the adult distal spermatheca and weakly in the proximal sheath. [Source: WormBase]
C09B8.5	C09B8.5	C09B8.5	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C09B8.7	C09B8.7a.1	pak-1	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	pak-1 encodes, by alternative splicing, at least five isoforms of a putative p21-activated kinase orthologous to human PAK1, PAK2 (OMIM:?), and PAK3 (OMIM:300142, mutated in nonsyndromic mental retardation). PAK-1 is required (redundantly with its paralog, MAX-2) for normal axonal guidance of motoneurons, P cell migration, and locomotion, with max-2(cy2).pak-1(ok448) double mutants phenotypically resembling unc-73 or ced-10.mig-2 mutants. pak-1 is expressed in pharyngeal muscles, CAN neurons, ventral cord motoneurons, migrating distal tip cells, developing uterus, B, Y, and T cells in the male tail, and vulval muscle cells. by itself, the null pak-1(ok448) mutation has no known phenotype. [Source: WormBase]
C09B8.7	C09B8.7a.2	pak-1	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl	pak-1 encodes, by alternative splicing, at least five isoforms of a putative p21-activated kinase orthologous to human PAK1, PAK2 (OMIM:?), and PAK3 (OMIM:300142, mutated in nonsyndromic mental retardation). PAK-1 is required (redundantly with its paralog, MAX-2) for normal axonal guidance of motoneurons, P cell migration, and locomotion, with max-2(cy2).pak-1(ok448) double mutants phenotypically resembling unc-73 or ced-10.mig-2 mutants. pak-1 is expressed in pharyngeal muscles, CAN neurons, ventral cord motoneurons, migrating distal tip cells, developing uterus, B, Y, and T cells in the male tail, and vulval muscle cells. by itself, the null pak-1(ok448) mutation has no known phenotype. [Source: WormBase]
C09G1.2	C09G1.2	C09G1.2	2	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C09G1.3	C09G1.3	C09G1.3	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C10A4.9	C10A4.9	C10A4.9	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C10E2.4	C10E2.4	C10E2.4	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C10E2.5	C10E2.5	C10E2.5	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C11E4.3	C11E4.3	tag-263	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C11H1.3	C11H1.3	C11H1.3	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C11H1.4	C11H1.4a	prx-1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl	prx-1 encodes a predicted peroxin, a subfamily 2 member of the AAA (ATPases Associated with diverse cellular Activities) family that affects growth in one large-scale RNAi screen. expressed in intestinal cells throughout development. [Source: WormBase]
C11H1.5	C11H1.5	C11H1.5	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C11H1.9	C11H1.9a	C11H1.9	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C11H1.9	C11H1.9b	C11H1.9	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C14A11.7	C14A11.7	ssr-2	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C14E2.2	C14E2.2	C14E2.2	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C14F11.1	C14F11.1a	C14F11.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C14F11.1	C14F11.1b.1	C14F11.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C14F11.1	C14F11.1b.2	C14F11.1	1	23 X	Forward	View as cDNA map \| View as Table	Internal \| Ensembl
C14H10.1	C14H10.1.1	C14H10.1	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C14H10.1	C14H10.1.2	C14H10.1	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C15A7.2	C15A7.2	C15A7.2	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C15B12.4	C15B12.4	C15B12.4	3	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl
C15B12.6	C15B12.6	C15B12.6	1	23 X	Reverse	View as cDNA map \| View as Table	Internal \| Ensembl

Gene ID

Transcript ID

Common Gene Name

# of miRNA targets
for specified miRNAs

Chromosome

Strand Direction

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Gene Link

Description

AC8.10

23 X

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AC8.3

23 X

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B0198.3

B0198.3a

B0198.3

23 X

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B0272.1

tbb-4

23 X

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B0272.2

memb-1

23 X

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B0272.4

23 X

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B0302.1

B0302.1a.1

kin-25

23 X

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kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]

B0302.1

B0302.1a.2

kin-25

23 X

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kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]

B0302.1

B0302.1b

kin-25

23 X

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kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]

B0310.3

23 X

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B0395.2

mboa-1

23 X

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mboa-1 encodes a putative acyl-Coenzyme A:cholesterol ('sterol') O-acyltransferase, orthologous to human SOAT1 (OMIM:102642). MBOA-1 is required for normal locomotion and normally long lifespan in mass RNAi assays. mboa-1 is expressed in the seam cells and nervous systems of larvae and adults, and in the adult reproductive system. [Source: WormBase]

B0403.2

ubc-17

23 X

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B0403.5

23 X

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B0410.2

B0410.2a

vang-1

23 X

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vang-1 encodes an ortholog of Drosophila VAN GOGH (also known as STRABISMUS). VANG-1 enables Wnt-directed planar cell polarity. VANG-1 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak. [Source: WormBase]

B0410.2

B0410.2b

vang-1

23 X

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B0416.1

23 X

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B0416.4

23 X

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B0416.6

gly-13

23 X

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gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates. gly-13 is expressed throughout development in many cell types. gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14. [Source: WormBase]

B0563.10

23 X

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B0563.6

B0563.6a

B0563.6

23 X

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B0563.6

B0563.6b.1

B0563.6

23 X

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B0563.6

B0563.6b.2

B0563.6

23 X

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B0563.6

B0563.6c

B0563.6

23 X

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C01C4.3

C01C4.3b

C01C4.3

23 X

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C01C4.3 encodes a serine/threonine protein kinase. [Source: WormBase]

C02B4.1

adt-1

23 X

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The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis. [Source: WormBase]

C02B8.1

C02B8.1.1

C02B8.1

23 X

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C02B8.1

C02B8.1.2

C02B8.1

23 X

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C02B8.5

23 X

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C02B8.5 encodes a homolog of the functionally active Fmrf Receptor (FR. CG2114) of D. melanogaster. it is thus possible that C02B8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). [Source: WormBase]

C02C6.2

C02C6.2a

olrn-1

23 X

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olrn-1 encodes, by alternative splicing, two isoforms of a transmembrane protein required for differentiation of the AWC[ON] neuron, expression of str-2 in AWC[ON], adaptation to benzaldehyde, chemotaxis to butanone, and enhancement of chemotaxis to butanone by the presence of food. OLRN-1 is orthologous to Drosophila melanogaster RAW and Schistosoma japonicum SJCHGC05616. while OLRN-1 has orthologs in nematodes, trematodes, and arthropods, its has no obvious chordate homologs. OLRN-6 is expressed in many pharyngeal neurons and some head neurons, but is required solely in the AWC[ON] neuron for butanone enhancement. OLRN-6's function in butanone enhancement is both serotonin- and dopamine-independent, and appears to also act in chemotactic enhancement of 2,3-pentanedione and isoamyl alcohol. by orthology with RAW, OLRN-6 is predicted to inhibit JNK-1 signalling, which may in turn allow the asymmetrical AWC[ON] fate to emerge. [Source: WormBase]

C02C6.2

C02C6.2b

olrn-1

23 X

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C02C6.3

C02C6.3a

C02C6.3

23 X

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C02D4.1

jud-4

23 X

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jud-4 encodes an unfamiliar protein, putatively secreted, that is required both for normal sensitivity to ethanol and for survival after freezing and thawing. JUD-4 is expressed in hypodermis and vulval muscles. JUD-4 is orthologous to Brugia malayi Bm1_40315, but lacks obvious orthologies to non-nematode proteins. JUD-4's C-terminal domain has possible similarity to F40E10.5, and to proteins such as human HOMER1. jud-4(ys18) mutants show delayed sensitivity to ethanol levels that rapidly paralyze normal worms, but do not survive freezing and rethawing as does wild-type. JUD-4 has no obvious function in mass RNAi assays. [Source: WormBase]

C02F12.1

C02F12.1b

tsp-17

23 X

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C02F12.4

tag-52

23 X

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C02F12.8

23 X

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C02H7.1

dyf-11

23 X

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dyf-11 encodes a conserved protein orthologous to the human microtubule-binding protein MIP-T3 and that contains a lysine-rich region and a C-terminal coiled-coil domain present in a number of intraflagellar transport (IFT) complex B proteins. DYF-11 activity is required continuously in sensory neurons for formation of medial and distal ciliary segments and thus, for normal sensory cilium morphology and function and chemotaxis. a dyf-11::gfp promoter fusion is expressed in all ciliated sensory neurons as well as in the AQR, PQR, ADE, and PDR neurons. a DYF-11::GFP protein fusion is detected throughout the cilium and appears to localize to IFT-B particles in a manner consistent with an early role in IFT-B particle assembly. dyf-11 expression in ciliated neurons is dependent upon the presence of the DAF-19 RFX transcription factor. [Source: WormBase]

C02H7.3

C02H7.3a

aex-3

23 X

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aex-3 encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584). AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively. AEX-3 is also required for egg laying and locomotion. AEX-3 is expressed in nearly all neurons. [Source: WormBase]

C03B1.4

23 X

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C03B1.7

23 X

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C03B1.9

23 X

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C03F11.1

23 X

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C03F11.4

C03F11.4.1

C03F11.4

23 X

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C03F11.4

C03F11.4.2

C03F11.4

23 X

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C03F11.4

C03F11.4.3

C03F11.4

23 X

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C03H12.1

23 X

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C04A11.1

23 X

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C04A11.3

gck-4

23 X

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C04A11.4

adm-2

23 X

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adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family). like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. [Source: WormBase]

C04C11.1

C04C11.1a

C04C11.1

23 X

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C05A9.2

23 X

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C05C9.3

23 X

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The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). [Source: WormBase]

C05E11.7

23 X

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C05E7.2

23 X

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C05E7.3

23 X

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C05G5.1

23 X

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C05G5.5

23 X

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C06G1.2

23 X

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C06G1.4

C06G1.4.1

ain-1

23 X

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ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]

C06G1.4

C06G1.4.2

ain-1

23 X

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C07A12.1

C07A12.1a

ham-2

23 X

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The ham-2 gene encodes a C2H2 zinc finger-containing protein required for proper migration of the hermaphrodite-specific neurons (HSNs) and proper attachment of the pharynx to the nose. HAM-2 is expressed in the nuclei of the HSNs during migration, and acts downstream of EGL-5, a posterior group Hox protein, in HSN specification. HAM-2 acts redundantly with UNC-86 to downregulate UNC-43 expression in the HSNs after migration is complete. [Source: WormBase]

C07A12.1

C07A12.1b

ham-2

23 X

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C07A12.1

C07A12.1c

ham-2

23 X

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C07A12.3

C07A12.3a

nhr-35

23 X

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C07A12.5

C07A12.5a

spr-3

23 X

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C07A12.7

C07A12.7a.1

C07A12.7

23 X

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C07A12.7

C07A12.7a.2

C07A12.7

23 X

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C07A12.7

C07A12.7b

C07A12.7

23 X

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C07A12.7

C07A12.7c.1

C07A12.7

23 X

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C07A4.1

tiar-3

23 X

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C07B5.4

C07B5.4a.1

C07B5.4

23 X

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C07B5.4

C07B5.4a.2

C07B5.4

23 X

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C07B5.4

C07B5.4b.1

C07B5.4

23 X

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C07B5.4

C07B5.4b.2

C07B5.4

23 X

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C08A9.1

sod-3

23 X

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sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan. sod-3 mRNA levels are diminished by mutation of daf-16 and chromatin immunoprecipitation (ChIP) studies demonstrate that DAF-16 can directly bind the sod-3 promoter. heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress. [Source: WormBase]

C08A9.6

23 X

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C09B8.1

ipp-5

23 X

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ipp-5 encodes a type I inositol 5-phosphatase homolog. ipp-5 acts downstream of let-23 to negatively regulate IP3 signaling and is involved in spermathecal contractions during ovulation. an ipp-5::gfp transcriptional reporter is expressed in the adult distal spermatheca and weakly in the proximal sheath. [Source: WormBase]

C09B8.5

23 X

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C09B8.7

C09B8.7a.1

pak-1

23 X

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pak-1 encodes, by alternative splicing, at least five isoforms of a putative p21-activated kinase orthologous to human PAK1, PAK2 (OMIM:?), and PAK3 (OMIM:300142, mutated in nonsyndromic mental retardation). PAK-1 is required (redundantly with its paralog, MAX-2) for normal axonal guidance of motoneurons, P cell migration, and locomotion, with max-2(cy2).pak-1(ok448) double mutants phenotypically resembling unc-73 or ced-10.mig-2 mutants. pak-1 is expressed in pharyngeal muscles, CAN neurons, ventral cord motoneurons, migrating distal tip cells, developing uterus, B, Y, and T cells in the male tail, and vulval muscle cells. by itself, the null pak-1(ok448) mutation has no known phenotype. [Source: WormBase]

C09B8.7

C09B8.7a.2

pak-1

23 X

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C09G1.2

23 X

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C09G1.3

23 X

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C10A4.9

23 X

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C10E2.4

23 X

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C10E2.5

23 X

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C11E4.3

tag-263

23 X

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C11H1.3

23 X

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C11H1.4

C11H1.4a

prx-1

23 X

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prx-1 encodes a predicted peroxin, a subfamily 2 member of the AAA (ATPases Associated with diverse cellular Activities) family that affects growth in one large-scale RNAi screen. expressed in intestinal cells throughout development. [Source: WormBase]

C11H1.5

23 X

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C11H1.9

C11H1.9a

C11H1.9

23 X

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