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Genome: Caenorhabditis Elegans | mRNA | miRBase 18 (Nov. 2011), ENSEMBL 65 (Dec. 2011) and RNA22v1.0
Description: List of transcripts that are targeted by all of the below miRNA identifiers simultaneously
miRNA's: cel-miR-1-5p (MIMAT0020301)
Filtering By: Base pair min value: 12 | Folding energy max value (Kcal/mol): -21 | Min miRNA targets: 1


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Gene IDTranscript IDCommon Gene Name# of miRNA targets
for specified miRNAs
ChromosomeStrand DirectionTranscript Link to view miRNA target predictionsGene LinkDescription
B0198.3B0198.3aB0198.3123 XReverseView as cDNA map |
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Ensembl
B0272.1B0272.1tbb-4123 XReverseView as cDNA map |
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Ensembl
B0302.1B0302.1a.1kin-25223 XForwardView as cDNA map |
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Ensembl
kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]
B0302.1B0302.1a.2kin-25223 XForwardView as cDNA map |
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Ensembl
kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]
B0302.1B0302.1bkin-25223 XForwardView as cDNA map |
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Ensembl
kin-25 encodes a nonreceptor tyrosine kinase that is a member of the Ack subfamily of cytoplasmic tyrosine kinases. [Source: WormBase]
B0395.1B0395.1nhx-1123 XForwardView as cDNA map |
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nhx-1 encodes a sodium/proton exchanger expressed intracellularly within hypodermal and muscle cells. NHX-1 is required for embryonic viability, and is thought to prevent intracellular acidification by catalysing the electroneutral exchange of vesicular sodium for an intracellular proton. [Source: WormBase]
B0563.4B0563.4.1tmbi-4123 XForwardView as cDNA map |
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Ensembl
B0563.4B0563.4.2tmbi-4123 XForwardView as cDNA map |
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Ensembl
C02B4.1C02B4.1adt-1123 XForwardView as cDNA map |
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Ensembl
The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis. [Source: WormBase]
C02B8.5C02B8.5C02B8.5123 XReverseView as cDNA map |
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Ensembl
C02B8.5 encodes a homolog of the functionally active Fmrf Receptor (FR. CG2114) of D. melanogaster. it is thus possible that C02B8.5 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12). [Source: WormBase]
C02C6.1C02C6.1adyn-1123 XForwardView as cDNA map |
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dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase]
C02C6.1C02C6.1bdyn-1123 XForwardView as cDNA map |
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dyn-1 encodes the C. elegans ortholog of the dynamin GTPase. dyn-1 activity is required for endocytosis, synaptic vesicle recycling, cytokinesis, and the CED-1 pathway that regulates engulfment and degradation of apoptotic cells. mutations in dyn-1 affect locomotion, egg-laying, defecation, and embryonic development, indicating that dyn-1's endocytic function is required for a number of diverse processes. dyn-1 reporter fusion constructs are expressed in motor neurons, intestinal cells, and pharyngeal muscle. [Source: WormBase]
C02F12.5C02F12.5C02F12.5123 XReverseView as cDNA map |
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C02F12.5 encodes a putatively secreted protein with a Kunitz/bovine pancreatic trypsin inhibitor domain. C02F12.5 has no obvious function in mass RNAi assays. [Source: WormBase]
C02H7.3C02H7.3aaex-3223 XReverseView as cDNA map |
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aex-3 encodes a guanine nucleotide exchange factor for the rab-3 GTPase that is orthologous to human MAP kinase activating protein containing death domain (MADD, OMIM:603584). AEX-3 is required for intracellular vesicle trafficking as well as synaptic vesicle release and interacts with CAB-1 and RAB-3 to regulate separate pathways for neural activities such as defecation and male mating, respectively. AEX-3 is also required for egg laying and locomotion. AEX-3 is expressed in nearly all neurons. [Source: WormBase]
C03A3.2C03A3.2.1C03A3.2123 XForwardView as cDNA map |
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C03A3.2C03A3.2.2C03A3.2123 XForwardView as cDNA map |
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C03B1.3C03B1.3C03B1.3123 XForwardView as cDNA map |
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C03F11.1C03F11.1C03F11.1123 XForwardView as cDNA map |
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C04A11.3C04A11.3gck-4123 XForwardView as cDNA map |
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C04A11.4C04A11.4adm-2123 XForwardView as cDNA map |
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adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family). like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. [Source: WormBase]
C05D9.3C05D9.3C05D9.3123 XForwardView as cDNA map |
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C05E11.5C05E11.5amt-4123 XForwardView as cDNA map |
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amt-4 encodes a member of the ammonium transporter protein family. [Source: WormBase]
C05E7.4C05E7.4C05E7.4223 XForwardView as cDNA map |
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C05G5.5C05G5.5C05G5.5123 XReverseView as cDNA map |
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C06G1.1C06G1.1aC06G1.1123 XForwardView as cDNA map |
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C06G1.1C06G1.1bC06G1.1123 XForwardView as cDNA map |
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C06G1.4C06G1.4.1ain-1223 XForwardView as cDNA map |
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ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]
C06G1.4C06G1.4.2ain-1223 XForwardView as cDNA map |
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ain-1 encodes an unfamiliar protein synergistically required, with LIN-31, for the normal timing of vulval differentiation, independently of LET-60/RAS, and parallel to or downstream of LIN-14/LIN-28/HBL-1. AIN-1 is expressed in cytoplasmic foci (that are probably P bodies) in several tissues, including vulval precursor cells and neurons. AIN-1 coimmunoprecipitates with DCR-1 and ALG-1, also binds ALG-1 in vitro, and does not require DNA or RNA for its binding. in vivo, AIN-1 targets ALG-1 to cytoplasmic foci, in which it colocalizes with DCAP-2. AIN-1 is likely to be a RISC component, since anti-AIN-1 antibodies precipitate 29 different miRNAs, including mir-2, mir-52, mir-58, mir-71, mir-77, and mir-239a. ain-1(ku322) mutants are essentially wild-type, except for sporadically gapped alae and excess seam cell nuclei arising from retarded seam cell fusion. more prominently, ain-1(ku322) suppresses the multivulva phenotype of lin-31(n1053) mutations, while strongly enhancing lin-31(n1053)'s egg-laying defect. the cellular basis of lin-31(n1053).ain-1(ku322) phenotypes is a delay in vulval development in L4 larvae not seen with either mutation alone. ain-1(ku322) has no effect on let-60(n1046) or lin-3(e1275) mutations. ain-1(ku322) suppresses the precocious vulval development of lin-14(RNAi), lin-28 mutants, and hbl-1(RNAi). alg-1 or alg-1 ain-1 mutant alae resemble ain-1 alae, indicating that ALG-1 and AIN-1 act in a common genetic pathway. AIN-1 is homologous to Brugia malayi 14748.m00068, 14052.m00191, and 14963.m01790, and paralogous to C. elegans B0041.2. AIN-1 and its nematode homologs have weak similarity to human TNRC6A (GW182. OMIM:610739) and Drosophila GAWKY. [Source: WormBase]
C06G1.5C06G1.5C06G1.5223 XReverseView as cDNA map |
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C08A9.3C08A9.3aC08A9.3123 XReverseView as cDNA map |
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C09B7.1C09B7.1aser-7123 XForwardView as cDNA map |
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ser-7 encodes an ortholog of mammalian 5-HT7 metabotropic serotonin receptors. SER-7 is required for stimulation of egg-laying or pharyngeal pumping by serotonin (5-HT), for regular pumping in response to bacteria, and probably also for 5-HT to activate MC neurons. SER-7 and SER-1 are redundantly required for normal egg-laying. SER-7 is expressed in head and tail neurons, pharyngeal neurons (M4, MCs, I2s, I3, M5, M3s, I4, I6, and M2s), vulval muscles, and intestine. heterologously expressed SER-7, when challenged with 5-HT, stimulates intracellular adenylate cyclase activity. SER-7 has high affinity for 5-HT and tryptamine, but not for 5-CT, and is unaffected by at least some agonists of mammalian 5-HT7 receptors. [Source: WormBase]
C09B7.1C09B7.1bser-7123 XForwardView as cDNA map |
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ser-7 encodes an ortholog of mammalian 5-HT7 metabotropic serotonin receptors. SER-7 is required for stimulation of egg-laying or pharyngeal pumping by serotonin (5-HT), for regular pumping in response to bacteria, and probably also for 5-HT to activate MC neurons. SER-7 and SER-1 are redundantly required for normal egg-laying. SER-7 is expressed in head and tail neurons, pharyngeal neurons (M4, MCs, I2s, I3, M5, M3s, I4, I6, and M2s), vulval muscles, and intestine. heterologously expressed SER-7, when challenged with 5-HT, stimulates intracellular adenylate cyclase activity. SER-7 has high affinity for 5-HT and tryptamine, but not for 5-CT, and is unaffected by at least some agonists of mammalian 5-HT7 receptors. [Source: WormBase]
C09B8.7C09B8.7a.1pak-1123 XReverseView as cDNA map |
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pak-1 encodes, by alternative splicing, at least five isoforms of a putative p21-activated kinase orthologous to human PAK1, PAK2 (OMIM:?), and PAK3 (OMIM:300142, mutated in nonsyndromic mental retardation). PAK-1 is required (redundantly with its paralog, MAX-2) for normal axonal guidance of motoneurons, P cell migration, and locomotion, with max-2(cy2).pak-1(ok448) double mutants phenotypically resembling unc-73 or ced-10.mig-2 mutants. pak-1 is expressed in pharyngeal muscles, CAN neurons, ventral cord motoneurons, migrating distal tip cells, developing uterus, B, Y, and T cells in the male tail, and vulval muscle cells. by itself, the null pak-1(ok448) mutation has no known phenotype. [Source: WormBase]
C09B8.7C09B8.7a.2pak-1123 XReverseView as cDNA map |
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pak-1 encodes, by alternative splicing, at least five isoforms of a putative p21-activated kinase orthologous to human PAK1, PAK2 (OMIM:?), and PAK3 (OMIM:300142, mutated in nonsyndromic mental retardation). PAK-1 is required (redundantly with its paralog, MAX-2) for normal axonal guidance of motoneurons, P cell migration, and locomotion, with max-2(cy2).pak-1(ok448) double mutants phenotypically resembling unc-73 or ced-10.mig-2 mutants. pak-1 is expressed in pharyngeal muscles, CAN neurons, ventral cord motoneurons, migrating distal tip cells, developing uterus, B, Y, and T cells in the male tail, and vulval muscle cells. by itself, the null pak-1(ok448) mutation has no known phenotype. [Source: WormBase]
C09C7.1C09C7.1zig-4123 XForwardView as cDNA map |
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zig-4 encodes a predicted secreted protein that is a member of the immunoglobulin superfamily of proteins. ZIG-4 activity is required for maintenance of ventral nerve cord organization: the AVKL/R and PVQL/R axons of the left and right ventral nerve cords do not maintain their proper spatial positions and drift into the opposite cord. a zig-4::gfp reporter fusion is expressed in the PVT, ASK, BAG, and M2 neurons, with expression also seen during the L1 stage in pharyngeal mesoderm and ectoderm. [Source: WormBase]
C09E10.2C09E10.2adgk-1223 XReverseView as cDNA map |
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dgk-1 encodes an ortholog of mammalian diacylglycerol kinase theta (DGKQ). dgk-1 activity functions downstream in a serotonin signaling pathway that regulates locomotion and synaptic transmission. in addition, dgk-1 activity negatively regulates egg laying. dgk-1 genetically interacts with the goa-1 and egl-30 signaling pathways. a GFP::DGK-1 reporter fusion protein is expressed in the excretory canals and in most neurons, including the ventral cord neurons. in neurons, GFP::DGK-1 localizes to axons and cell bodies. when expressed ectopically in HEK293 cells, DGK-1 exhibits DAG kinase activity. [Source: WormBase]
C09E10.2C09E10.2bdgk-1223 XReverseView as cDNA map |
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dgk-1 encodes an ortholog of mammalian diacylglycerol kinase theta (DGKQ). dgk-1 activity functions downstream in a serotonin signaling pathway that regulates locomotion and synaptic transmission. in addition, dgk-1 activity negatively regulates egg laying. dgk-1 genetically interacts with the goa-1 and egl-30 signaling pathways. a GFP::DGK-1 reporter fusion protein is expressed in the excretory canals and in most neurons, including the ventral cord neurons. in neurons, GFP::DGK-1 localizes to axons and cell bodies. when expressed ectopically in HEK293 cells, DGK-1 exhibits DAG kinase activity. [Source: WormBase]
C09E10.2C09E10.2cdgk-1223 XReverseView as cDNA map |
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dgk-1 encodes an ortholog of mammalian diacylglycerol kinase theta (DGKQ). dgk-1 activity functions downstream in a serotonin signaling pathway that regulates locomotion and synaptic transmission. in addition, dgk-1 activity negatively regulates egg laying. dgk-1 genetically interacts with the goa-1 and egl-30 signaling pathways. a GFP::DGK-1 reporter fusion protein is expressed in the excretory canals and in most neurons, including the ventral cord neurons. in neurons, GFP::DGK-1 localizes to axons and cell bodies. when expressed ectopically in HEK293 cells, DGK-1 exhibits DAG kinase activity. [Source: WormBase]
C09E10.2C09E10.2ddgk-1223 XReverseView as cDNA map |
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dgk-1 encodes an ortholog of mammalian diacylglycerol kinase theta (DGKQ). dgk-1 activity functions downstream in a serotonin signaling pathway that regulates locomotion and synaptic transmission. in addition, dgk-1 activity negatively regulates egg laying. dgk-1 genetically interacts with the goa-1 and egl-30 signaling pathways. a GFP::DGK-1 reporter fusion protein is expressed in the excretory canals and in most neurons, including the ventral cord neurons. in neurons, GFP::DGK-1 localizes to axons and cell bodies. when expressed ectopically in HEK293 cells, DGK-1 exhibits DAG kinase activity. [Source: WormBase]
C09E10.2C09E10.2edgk-1223 XReverseView as cDNA map |
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dgk-1 encodes an ortholog of mammalian diacylglycerol kinase theta (DGKQ). dgk-1 activity functions downstream in a serotonin signaling pathway that regulates locomotion and synaptic transmission. in addition, dgk-1 activity negatively regulates egg laying. dgk-1 genetically interacts with the goa-1 and egl-30 signaling pathways. a GFP::DGK-1 reporter fusion protein is expressed in the excretory canals and in most neurons, including the ventral cord neurons. in neurons, GFP::DGK-1 localizes to axons and cell bodies. when expressed ectopically in HEK293 cells, DGK-1 exhibits DAG kinase activity. [Source: WormBase]
C09G1.4C09G1.4C09G1.4123 XReverseView as cDNA map |
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C10E2.2C10E2.2.1C10E2.2123 XForwardView as cDNA map |
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This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. [Source: WormBase]
C10E2.3C10E2.3hda-4123 XForwardView as cDNA map |
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hda-4 encodes a class II histone deacetylase that contains a putative MEF-2 DNA binding domain, a nuclear localization signal domain, and a single catalytic domain and may affect locomotion, body morphology, and growth. interacts with MEF-2 in in vitro assays and is expressed in body-wall muscle, neurons, and hypodermal seam cells [Source: WormBase]
C10E2.6C10E2.6.1C10E2.6123 XReverseView as cDNA map |
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C10E2.6C10E2.6.2C10E2.6123 XReverseView as cDNA map |
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C11H1.3C11H1.3C11H1.3223 XReverseView as cDNA map |
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C11H1.7C11H1.7C11H1.7123 XForwardView as cDNA map |
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C12D12.5C12D12.5sox-4123 XReverseView as cDNA map |
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C14E2.2C14E2.2C14E2.2123 XReverseView as cDNA map |
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C14F11.1C14F11.1aC14F11.1123 XForwardView as cDNA map |
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C14F11.1C14F11.1b.1C14F11.1123 XForwardView as cDNA map |
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C14H10.2C14H10.2aC14H10.2123 XReverseView as cDNA map |
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C14H10.2C14H10.2b.2C14H10.2123 XReverseView as cDNA map |
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C14H10.3C14H10.3b.1C14H10.3123 XReverseView as cDNA map |
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C15B12.1C15B12.1C15B12.1123 XForwardView as cDNA map |
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C15B12.2C15B12.2.1C15B12.2123 XForwardView as cDNA map |
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C15B12.2C15B12.2.2C15B12.2123 XForwardView as cDNA map |
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C15B12.7C15B12.7bcdf-1223 XReverseView as cDNA map |
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a cation diffusion facilitator protein, affects vulva development, genetically interacts with let-60/ras signaling pathway. and is expressed in the vulval muscles, the intestinal cells, and in the vulval precursor cells. [Source: WormBase]
C15C7.2C15C7.2.1klp-8123 XForwardView as cDNA map |
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klp-8 encodes an atypical kinesin-like motor protein with the motor domain in the N-terminus. the motor domain of KLP-8 exhibits poor homology to the globular motor domain of the kinesin heavy chain. [Source: WormBase]
C15C7.2C15C7.2.2klp-8123 XForwardView as cDNA map |
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klp-8 encodes an atypical kinesin-like motor protein with the motor domain in the N-terminus. the motor domain of KLP-8 exhibits poor homology to the globular motor domain of the kinesin heavy chain. [Source: WormBase]
C15H9.5C15H9.5.1C15H9.5123 XForwardView as cDNA map |
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C15H9.5C15H9.5.2C15H9.5123 XForwardView as cDNA map |
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C16B8.4C16B8.4C16B8.4123 XReverseView as cDNA map |
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C16E9.2C16E9.2aC16E9.2123 XForwardView as cDNA map |
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C16H3.3C16H3.3aC16H3.3123 XReverseView as cDNA map |
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C16H3.3C16H3.3bC16H3.3123 XReverseView as cDNA map |
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C17G1.3C17G1.3augt-23123 XReverseView as cDNA map |
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C17G1.3C17G1.3b.1ugt-23123 XReverseView as cDNA map |
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C17G1.3C17G1.3b.2ugt-23123 XReverseView as cDNA map |
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C17G1.6C17G1.6anas-37123 XReverseView as cDNA map |
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nas-37 encodes a Astacin-class metalloprotease required for full ecdysis that is expressed in hypodermal cells 4 hours before each ecdysis. NAS-37 protein has an N-terminal signal sequence followed by an Astacin protease domain and three protein-binding domains (EGF-like, CUB, and thrombospondin). NAS-37 accumulates in anterior cuticle, being shed with it after ecdysis. nas-37 mutants fail to complete anterior ecdysis at each molt. nas-37(ox196) mutations alter an evolutionarily invariant histidine residue yet are phenotypically indistinguishable from null mutations, consistent with the hypothesis that NAS-37 encodes a functional protease. NAS-37 orthologs are found in other nematodes such as Brugia malayi. [Source: WormBase]
C17H11.2C17H11.2C17H11.2123 XForwardView as cDNA map |
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C17H11.6C17H11.6aC17H11.6423 XReverseView as cDNA map |
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C17H11.6C17H11.6bC17H11.6423 XReverseView as cDNA map |
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C17H11.6C17H11.6c.1C17H11.6423 XReverseView as cDNA map |
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C17H11.6C17H11.6c.2C17H11.6423 XReverseView as cDNA map |
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C17H11.6C17H11.6c.3C17H11.6423 XReverseView as cDNA map |
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C17H11.6C17H11.6dC17H11.6423 XReverseView as cDNA map |
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C18B12.3C18B12.3dsc-1123 XReverseView as cDNA map |
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C18B2.2C18B2.2C18B2.2123 XForwardView as cDNA map |
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C18B2.5C18B2.5a.1C18B2.5123 XReverseView as cDNA map |
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C18B2.5C18B2.5a.2C18B2.5123 XReverseView as cDNA map |
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C18B2.5C18B2.5bC18B2.5123 XReverseView as cDNA map |
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C23F12.1C23F12.1afln-2123 XForwardView as cDNA map |
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C23F12.1C23F12.1cfln-2123 XForwardView as cDNA map |
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C23F12.1C23F12.1dfln-2123 XForwardView as cDNA map |
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C23H4.4C23H4.4aC23H4.4123 XForwardView as cDNA map |
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C23H4.6C23H4.6aC23H4.6123 XForwardView as cDNA map |
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C23H4.6C23H4.6bC23H4.6123 XForwardView as cDNA map |
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C24A8.1C24A8.1dop-6123 XForwardView as cDNA map |
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dop-6 encodes an homolog of mammalian D2 or D3 dopamine receptors, and a paralog of DOP-2/-3. dop-6 is expressed in the nervous system. because of its paralogy, DOP-6 might act redundantly with DOP-2 to promote the basal slowing response to bacterial feeding, or it might account for the residual response to excess dopamine seen in triple dop-1/-2/-3 mutants. but dop-6 otherwise has no obvious function in RNAi assays of brood size, egg laying, pharyngeal pumping, locomotion, or male mating. [Source: WormBase]
C24H10.1C24H10.1C24H10.1123 XForwardView as cDNA map |
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C24H10.1 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia. C24H10.1 is worm-specific, with obvious homologs only in C. elegans. C24H10.1 has no obvious function in mass RNAi assays. claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. [Source: WormBase]
C24H10.2C24H10.2C24H10.2123 XForwardView as cDNA map |
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C25A11.4C25A11.4aajm-1223 XForwardView as cDNA map |
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ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo. AJM-1 contains a coiled-coil motif. AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo. AJM-1 is mislocalized in a dlg-1(RNAi) background. LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia. CLC-1 colocalizes with AJM-1. vab-9 mutations enhance the adhesion defects of ajm-1 mutants. ajm-1 is expressed at the apical borders of all epithelia. [Source: WormBase]
C25A11.4C25A11.4bajm-1123 XForwardView as cDNA map |
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ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo. AJM-1 contains a coiled-coil motif. AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo. AJM-1 is mislocalized in a dlg-1(RNAi) background. LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia. CLC-1 colocalizes with AJM-1. vab-9 mutations enhance the adhesion defects of ajm-1 mutants. ajm-1 is expressed at the apical borders of all epithelia. [Source: WormBase]
C25A11.4C25A11.4dajm-1223 XForwardView as cDNA map |
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Ensembl
ajm-1 encodes a member of the apical junction molecule class that is required for correct elongation of the C. elegans embryo. AJM-1 contains a coiled-coil motif. AJM-1 binds DLG-1 in vitro, in yeast two-hybrid assays, and in vivo. AJM-1 is mislocalized in a dlg-1(RNAi) background. LET-413 is required for rapid confinement of DLG-1 and AJM-1 to a narrow apical region in C. elegans epithelia. CLC-1 colocalizes with AJM-1. vab-9 mutations enhance the adhesion defects of ajm-1 mutants. ajm-1 is expressed at the apical borders of all epithelia. [Source: WormBase]
C25B8.7C25B8.7C25B8.7123 XReverseView as cDNA map |
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C26B9.7C26B9.7C26B9.7223 XForwardView as cDNA map |
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C26G2.1C26G2.1syg-2123 XForwardView as cDNA map |
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syg-2 encodes a transmembrane protein that is a member of the immunoglobulin superfamily of proteins. during larval development, SYG-2 activity is required in vulval epithelial cells for proper synaptic specificity of the HSNL neuron. in regulating synapse formation, SYG-2 acts as a guidepost protein for the SYG-1 receptor that interacts with SYG-2 and acts within HSNL to regulate synaptic specificity. a SYG-2::GFP fusion protein is expressed in the primary vulval cell lineages beginning at the L3 larval stage, with expression increasing during the L4 stage and finally disappearing by adulthood. in embryos, SYG-2::GFP expression is detected in some head neurons and body wall muscles, the latter of which also express the reporter during the L1 and L2 larval stages. [Source: WormBase]
C27C12.3C27C12.3C27C12.3223 XReverseView as cDNA map |
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C27C12.3 encodes a novel protein that is conserved in C. elegans. three other genes related to C27C12.3 are present in tandem on the X chromosome. in situ hybridization studies indicate that C27C12.3 mRNA is expressed in the proximal germline. [Source: WormBase]
C27C12.7C27C12.7dpf-2223 XForwardView as cDNA map |
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C28G1.3C28G1.3sec-15123 XReverseView as cDNA map |
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Ensembl
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We gratefully acknowledge support of this work by the William M. Keck Foundation