Mitochondrial tRNA-lookalikes in nuclear chromosomes: Could they be functional?

The tRNA-lookalikes for human as well as more information on the identification of tRNA-lookalikes can be found here.

If you use any of the below please cite: Telonis AG, Kirino Y, Rigoutsos I (2015) Mitochondrial tRNA-lookalikes in nuclear chromosomes: Could they be functional? RNA Biology 12(4):375-380

In the paper “Mitochondrial tRNA-lookalikes in nuclear chromosomes: Could they be functional?”1 we discuss the possible functional roles of tRNA-lookalikes in the nuclear chromosomes. We also track the evolutionary history of the mitochondrial tRNA-lookalikes in nuclear chromosomes in 10 different species. The analysis was performed the same way as in our previous study2, which can also be found here. The data can be downloaded by the following buttons:

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File structure

For each organism, the list of tRNA-lookalikes is in tab-delimeted format. The columns are as follows:

  • Column 1: Chromosome or scaffold
  • Column 2: Strand
  • Column 3: Start coordinate of the tRNA-lookalike, inclusive
  • Column 4: End coordinate of the tRNA-lookalike, inclusive
  • Column 5: Best-matched mitochondrial tRNA coordinates
  • Column 6: Information about the mitochondrial tRNA (e.g. amino acid encoded)
  • Column 7: Percentage identity of the best-matched tRNA sequence with the genomic sequence of the tRNA-lookalike
  • Column 8: Number of mismatches between the sequence of the best-matched tRNA and the sequence of the tRNA-lookalike

References

  1. Telonis AG, Kirino Y, Rigoutsos I (2015) Mitochondrial tRNA-lookalikes in nuclear chromosomes: Could they be functional? RNA Biology 12(4):375-380
  2. Telonis AG, Loher P, Kirino Y, Rigoutsos I (2014) Nuclear and mitochondrial tRNA-lookalikes in the human genome. Frontiers in Genetics doi: 10.3389/fgene.2014.00344

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We gratefully acknowledge support of this work by the William M. Keck Foundation.

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