Home News New ALS Biomarkers Discovered for Prognosis and Diagnosis

New ALS Biomarkers Discovered for Prognosis and Diagnosis

In our paper “Re-Analyses of Samples From Amyotrophic Lateral Sclerosis Patients and Controls Identify Many Novel Small RNAs With Diagnostic And Prognostic Potential,” we identify many small RNA molecules that could potentially serve as diagnostic and prognostic biomarkers for Amyotrophic lateral sclerosis (ALS).

These biomarkers were generated from both plasma and serum datasets of ALS patients and comprise isoforms of microRNAs (miRNAs), transfer RNA-derived fragments (tRFs), ribosomal RNA-derived fragments (rRFs), Y RNA-derived fragments (yRFs), and also those of non-human origin (e.g. Burkholderiales and fungi).

These biomarkers are accessible by collecting blood, which makes them easier to obtain. It is our hope that they can be used to sensitively and specifically identify disease and improve prognosis.

SncRNAs from RNY4. Examples of sncRNAs that arise from RNY4 and are significantly differentially abundant between ALS and controls in both plasma and serum. Only sncRNAs with a mean normalized expression of <= 50 are shown and aligned to the full-length RNY4. Shown abundance represents mean values following DESeq2 normalization

References

  • Loher, P, Londin, E, Ilieva, H, Pasinelli, P, Rigoutsos, I. Re-Analyses of Samples From Amyotrophic Lateral Sclerosis Patients and Controls Identify Many Novel Small RNAs With Diagnostic And Prognostic Potential. Mol Neurobiol. 2025; :. doi: 10.1007/s12035-025-04747-2. PubMed PMID:39982687.

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