NEW YORK (GenomeWeb) – While it has been thought that in general microRNAs only bind to targets that perfectly match their seed regions, newly published data from Thomas Jefferson University researchers suggests that non-canonical binding may be even more widespread.
As such, the miRNA field has potentially been overlooking a significant number of valid miRNA targets as it explores the biological functions of the small, non-coding RNAs, according to Isidore Rigoutsos, director of the Computational Medicine Center at Thomas Jefferson University and senior author of the report. Read more on genomeweb.