Assistant Professor in Computational Medicine Center, Department of Pathology Eric Londin

Assistant Professor in Computational Medicine Center, Department of Pathology

Short Bio

Dr. Londin received his Ph.D. from Stony Brook University in Genetics. There, he studied the role of fibroblast growth factors in the early patterning of the nervous system. Following the completion of his Ph.D., he began working in the human genetics field as a research fellow at the Coriell Institute for Medical Research (Camden, NJ). While at Coriell, Dr. Londin, began working in the computational biology field, and specifically in population genetics. His worked focused on the identification of efficient ways to measure admixture within the human population. Since 2011, Dr. Londin has been a member of the Computational Medicine Center at Thomas Jefferson University, first as a postdoctoral research fellow, and currently as an assistant professor. His current work is focused on studying the human microRNA-ome (miRNAs). Of particular interest, is the characterization of the number and composition (miRNA isoforms or isomiRs) with in the human genome, as well as elucidating their roles in human disease. In addition to short-RNAs, Dr. Londin has an interest in DNA sequencing and its uses in a clinical setting. As next-generation sequencing becomes more prevelant in a clinical setting, have a better understanding of the benefits and limitations of this technology is of great importance. He has published numerous articles in the field of RNA and DNA sequencing, and sits on the editorial board and acts as a reviewer for multiple journals.

Publications

Papers

 

2018

  • Magee, RG, Telonis, AG, Loher, P, Londin, E, Rigoutsos, I. Profiles of miRNA Isoforms and tRNA Fragments in Prostate Cancer. Sci Rep. 2018;8 (1):5314. doi: 10.1038/s41598-018-22488-2. PubMed PMID:29593348 PubMed Central PMC5871839.
  • Sponziello, M, Benvenuti, S, Gentile, A, Pecce, V, Rosignolo, F, Virzì, AR, Milan, M, Comoglio, PM, Londin, E, Fortina, P, Barnabei, A, Appetecchia, M, Marandino, F, Russo, D, Filetti, S, Durante, C, Verrienti, A. Whole exome sequencing identifies a germline MET mutation in two siblings with hereditary wild-type RET medullary thyroid cancer. Hum. Mutat. 2018;39 (3):371-377. doi: 10.1002/humu.23378. PubMed PMID:29219214.
  • Pliatsika, V, Loher, P, Magee, R, Telonis, AG, Londin, E, Shigematsu, M, Kirino, Y, Rigoutsos, I. MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects. Nucleic Acids Res. 2018;46 (D1):D152-D159. doi: 10.1093/nar/gkx1075. PubMed PMID:29186503 PubMed Central PMC5753276.
  • Vahidnezhad, H, Youssefian, L, Saeidian, AH, Mahmoudi, H, Touati, A, Abiri, M, Kajbafzadeh, AM, Aristodemou, S, Liu, L, McGrath, JA, Ertel, A, Londin, E, Kariminejad, A, Zeinali, S, Fortina, P, Uitto, J. Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy. Matrix Biol. 2018;66 :22-33. doi: 10.1016/j.matbio.2017.11.003. PubMed PMID:29138120.

2017

  • Magee, R, Telonis, AG, Cherlin, T, Rigoutsos, I, Londin, E. Assessment of isomiR Discrimination Using Commercial qPCR Methods. Noncoding RNA. 2017;3 (2):. doi: 10.3390/ncrna3020018. PubMed PMID:28730153 PubMed Central PMC5514785.
  • Chand, SN, Zarei, M, Schiewer, MJ, Kamath, AR, Romeo, C, Lal, S, Cozzitorto, JA, Nevler, A, Scolaro, L, Londin, E, Jiang, W, Meisner-Kober, N, Pishvaian, MJ, Knudsen, KE, Yeo, CJ, Pascal, JM, Winter, JM, Brody, JR. Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors. Cancer Res. 2017;77 (18):5011-5025. doi: 10.1158/0008-5472.CAN-16-2704. PubMed PMID:28687616 PubMed Central PMC5663502.
  • Zarei, M, Lal, S, Parker, SJ, Nevler, A, Vaziri-Gohar, A, Dukleska, K, Mambelli-Lisboa, NC, Moffat, C, Blanco, FF, Chand, SN, Jimbo, M, Cozzitorto, JA, Jiang, W, Yeo, CJ, Londin, ER, Seifert, EL, Metallo, CM, Brody, JR, Winter, JM. Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells. Cancer Res. 2017;77 (16):4460-4471. doi: 10.1158/0008-5472.CAN-17-0015. PubMed PMID:28652247 PubMed Central PMC5922269.
  • Lal, S, Cheung, EC, Zarei, M, Preet, R, Chand, SN, Mambelli-Lisboa, NC, Romeo, C, Stout, MC, Londin, E, Goetz, A, Lowder, CY, Nevler, A, Yeo, CJ, Campbell, PM, Winter, JM, Dixon, DA, Brody, JR. CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype. Mol. Cancer Res. 2017;15 (6):696-707. doi: 10.1158/1541-7786.MCR-16-0361. PubMed PMID:28242812 PubMed Central PMC5466444.
  • Telonis, AG, Magee, R, Loher, P, Chervoneva, I, Londin, E, Rigoutsos, I. Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types. Nucleic Acids Res. 2017;45 (6):2973-2985. doi: 10.1093/nar/gkx082. PubMed PMID:28206648 PubMed Central PMC5389567.
  • Magee, R, Loher, P, Londin, E, Rigoutsos, I. Threshold-seq: a tool for determining the threshold in short RNA-seq datasets. Bioinformatics. 2017;33 (13):2034-2036. doi: 10.1093/bioinformatics/btx073. PubMed PMID:28203700 PubMed Central PMC5870860.

2016

  • Mogilyansky, E, Clark, P, Quann, K, Zhou, H, Londin, E, Jing, Y, Rigoutsos, I. Post-transcriptional Regulation of BRCA2 through Interactions with miR-19a and miR-19b. Front Genet. 2016;7 :143. doi: 10.3389/fgene.2016.00143. PubMed PMID:27630665 PubMed Central PMC5005319.
  • Paolillo, C, Londin, E, Fortina, P. Next generation sequencing in cancer: opportunities and challenges for precision cancer medicine. Scand. J. Clin. Lab. Invest. Suppl. 2016;245 :S84-91. doi: 10.1080/00365513.2016.1210331. PubMed PMID:27542004.
  • Zhou, H, Telonis, AG, Jing, Y, Xia, NL, Biederman, L, Jimbo, M, Blanco, F, Londin, E, Brody, JR, Rigoutsos, I. GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR. Cell Death Dis. 2016;7 :e2294. doi: 10.1038/cddis.2016.169. PubMed PMID:27415424 PubMed Central PMC4973341.
  • Farooqi, MS, Mitui, M, Londin, ER, Park, JY. High Concentration Capture Probes Enhance Massively Parallel Sequencing Assays. Clin. Chem. 2016;62 (7):1032-4. doi: 10.1373/clinchem.2016.255026. PubMed PMID:27217445.

2015

  • Blanco, FF, Jimbo, M, Wulfkuhle, J, Gallagher, I, Deng, J, Enyenihi, L, Meisner-Kober, N, Londin, E, Rigoutsos, I, Sawicki, JA, Risbud, MV, Witkiewicz, AK, McCue, PA, Jiang, W, Rui, H, Yeo, CJ, Petricoin, E, Winter, JM, Brody, JR. The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells. Oncogene. 2016;35 (19):2529-41. doi: 10.1038/onc.2015.325. PubMed PMID:26387536.
  • Londin, ER, Barash, CI. What is translational bioinformatics?. Appl Transl Genom. 2015;6 :1-2. doi: 10.1016/j.atg.2015.08.003. PubMed PMID:27054069 PubMed Central PMC4803779.
  • Telonis, AG, Loher, P, Jing, Y, Londin, E, Rigoutsos, I. Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity. Nucleic Acids Res. 2015;43 (19):9158-75. doi: 10.1093/nar/gkv922. PubMed PMID:26400174 PubMed Central PMC4627084.
  • Londin, E, Loher, P, Rigoutsos, I. Reply to Backes and Keller: Identification of novel tissue-specific and primate-specific human microRNAs. Proc. Natl. Acad. Sci. U.S.A. 2015;112 (22):E2851. doi: 10.1073/pnas.1505397112. PubMed PMID:25979943 PubMed Central PMC4460515.
  • Londin, E, Loher, P, Telonis, AG, Quann, K, Clark, P, Jing, Y, Hatzimichael, E, Kirino, Y, Honda, S, Lally, M, Ramratnam, B, Comstock, CE, Knudsen, KE, Gomella, L, Spaeth, GL, Hark, L, Katz, LJ, Witkiewicz, A, Rostami, A, Jimenez, SA, Hollingsworth, MA, Yeh, JJ, Shaw, CA, McKenzie, SE, Bray, P, Nelson, PT, Zupo, S, Van Roosbroeck, K, Keating, MJ, Calin, GA, Yeo, C, Jimbo, M, Cozzitorto, J, Brody, JR, Delgrosso, K, Mattick, JS, Fortina, P, Rigoutsos, I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc. Natl. Acad. Sci. U.S.A. 2015;112 (10):E1106-15. doi: 10.1073/pnas.1420955112. PubMed PMID:25713380 PubMed Central PMC4364231.
  • Park JY, Clark P, Londin E, Sponziello M, Kricka LJ, Fortina P. Clinical exome performance for reporting secondary genetic findings. Clin Chem. 2015 Jan;61(1):213-20. doi: 10.1373/clinchem.2014.231456. PubMed PMID:25414276 PubMed Central PMC4404496.

2014

  • Loher, P, Londin, ER, Rigoutsos, I. IsomiR expression profiles in human lymphoblastoid cell lines exhibit population and gender dependencies. Oncotarget. 2014;5 (18):8790-802. doi: 10.18632/oncotarget.2405. PubMed PMID:25229428 PubMed Central PMC4226722.
  • Park, JY, Kricka, LJ, Clark, P, Londin, E, Fortina, P. Clinical genomics: when whole genome sequencing is like a whole-body CT scan. Clin. Chem. 2014;60 (11):1390-2. doi: 10.1373/clinchem.2014.230276. PubMed PMID:25114273 PubMed Central PMC4396804.
  • Clark, PM, Loher, P, Quann, K, Brody, J, Londin, ER, Rigoutsos, I. Argonaute CLIP-Seq reveals miRNA targetome diversity across tissue types. Sci Rep. 2014;4 :5947. doi: 10.1038/srep05947. PubMed PMID:25103560 PubMed Central PMC4894423.
  • Londin, ER, Adijanto, J, Philp, N, Novelli, A, Vitale, E, Perria, C, Serra, G, Alesi, V, Surrey, S, Fortina, P. Donor splice-site mutation in CUL4B is likely cause of X-linked intellectual disability. Am. J. Med. Genet. A. 2014;164A (9):2294-9. doi: 10.1002/ajmg.a.36629. PubMed PMID:24898194 PubMed Central PMC4404493.
  • Lal, S, Burkhart, RA, Beeharry, N, Bhattacharjee, V, Londin, ER, Cozzitorto, JA, Romeo, C, Jimbo, M, Norris, ZA, Yeo, CJ, Sawicki, JA, Winter, JM, Rigoutsos, I, Yen, TJ, Brody, JR. HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells. Cancer Res. 2014;74 (4):1128-40. doi: 10.1158/0008-5472.CAN-13-1915. PubMed PMID:24536047 PubMed Central PMC4353573.
  • Londin, ER, Hatzimichael, E, Loher, P, Edelstein, L, Shaw, C, Delgrosso, K, Fortina, P, Bray, PF, McKenzie, SE, Rigoutsos, I. The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome. Biol. Direct. 2014;9 :3. doi: 10.1186/1745-6150-9-3. PubMed PMID:24524654 PubMed Central PMC3937023.

2013

  • Londin, E, Yadav, P, Surrey, S, Kricka, LJ, Fortina, P. Use of linkage analysis, genome-wide association studies, and next-generation sequencing in the identification of disease-causing mutations. Methods Mol. Biol. 2013;1015 :127-46. doi: 10.1007/978-1-62703-435-7_8. PubMed PMID:23824853.
  • Burkhart, RA, Pineda, DM, Chand, SN, Romeo, C, Londin, ER, Karoly, ED, Cozzitorto, JA, Rigoutsos, I, Yeo, CJ, Brody, JR, Winter, JM. HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer. RNA Biol. 2013;10 (8):1312-23. doi: 10.4161/rna.25274. PubMed PMID:23807417 PubMed Central PMC3817153.
  • Bray, PF, McKenzie, SE, Edelstein, LC, Nagalla, S, Delgrosso, K, Ertel, A, Kupper, J, Jing, Y, Londin, E, Loher, P, Chen, HW, Fortina, P, Rigoutsos, I. The complex transcriptional landscape of the anucleate human platelet. BMC Genomics. 2013;14 :1. doi: 10.1186/1471-2164-14-1. PubMed PMID:23323973 PubMed Central PMC3722126.
  • Benetatos, L, Hatzimichael, E, Londin, E, Vartholomatos, G, Loher, P, Rigoutsos, I, Briasoulis, E. The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis. Cell. Mol. Life Sci. 2013;70 (5):795-814. doi: 10.1007/s00018-012-1080-8. PubMed PMID:22825660.

2012

  • Pineda, DM, Rittenhouse, DW, Valley, CC, Cozzitorto, JA, Burkhart, RA, Leiby, B, Winter, JM, Weber, MC, Londin, ER, Rigoutsos, I, Yeo, CJ, Gorospe, M, Witkiewicz, AK, Sachs, JN, Brody, JR. HuR"s post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells. Cancer Biol. Ther. 2012;13 (10):946-55. doi: 10.4161/cbt.20952. PubMed PMID:22785201 PubMed Central PMC3414415.

2011

  • Londin, ER, Keller, MA, D"Andrea, MR, Delgrosso, K, Ertel, A, Surrey, S, Fortina, P. Whole-exome sequencing of DNA from peripheral blood mononuclear cells (PBMC) and EBV-transformed lymphocytes from the same donor. BMC Genomics. 2011;12 :464. doi: 10.1186/1471-2164-12-464. PubMed PMID:21943378 PubMed Central PMC3203102.

2010

  • Londin, ER, Keller, MA, Maista, C, Smith, G, Mamounas, LA, Zhang, R, Madore, SJ, Gwinn, K, Corriveau, RA. CoAIMs: a cost-effective panel of ancestry informative markers for determining continental origins. PLoS ONE. 2010;5 (10):e13443. doi: 10.1371/journal.pone.0013443. PubMed PMID:20976178 PubMed Central PMC2955551.

2007

  • Londin, ER, Mentzer, L, Sirotkin, HI. Churchill regulates cell movement and mesoderm specification by repressing Nodal signaling. BMC Dev. Biol. 2007;7 :120. doi: 10.1186/1471-213X-7-120. PubMed PMID:17980025 PubMed Central PMC2180179.
  • Londin, ER, Mentzer, L, Gates, KP, Sirotkin, HI. Expression and regulation of the zinc finger transcription factor Churchill during zebrafish development. Gene Expr. Patterns. 2007;7 (6):645-50. doi: 10.1016/j.modgep.2007.04.002. PubMed PMID:17521969 PubMed Central PMC1976285.

2005

  • Londin, ER, Niemiec, J, Sirotkin, HI. Chordin, FGF signaling, and mesodermal factors cooperate in zebrafish neural induction. Dev. Biol. 2005;279 (1):1-19. doi: 10.1016/j.ydbio.2004.11.016. PubMed PMID:15708554.

2004

  • Meşe, G, Londin, E, Mui, R, Brink, PR, White, TW. Altered gating properties of functional Cx26 mutants associated with recessive non-syndromic hearing loss. Hum. Genet. 2004;115 (3):191-9. doi: 10.1007/s00439-004-1142-6. PubMed PMID:15241677.

2003

  • Londin, ER, Meng, H, Gruen, JR. A transcription map of the 6p22.3 reading disability locus identifying candidate genes. BMC Genomics. 2003;4 (1):25. doi: 10.1186/1471-2164-4-25. PubMed PMID:12834540 PubMed Central PMC166143.

2002

  • Ahn, J, Won, TW, Kaplan, DE, Londin, ER, Kuzmic, P, Gelernter, J, Gruen, JR. A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression. Hum. Genet. 2002;111 (4-5):339-49. doi: 10.1007/s00439-002-0771-x. PubMed PMID:12384775.

To see the group's publications please click here or go to Research -> Publications

Contact Info