Yi Jing

Dr. Jing is a research associate at the Computational Medicine Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University. His research interests include the investigation of underlying mechanisms and functional behaviors of short and long non-coding RNAs in normal and disease states, the study of differential transcription of non-coding RNAs in tumors and other diseases, and the experimental validation of potential roles of RNAs predicted by computational analysis.

2020

• Cherlin, T, Magee, R, Jing, Y, Pliatsika, V, Loher, P, Rigoutsos, I. Ribosomal RNA fragmentation into short RNAs (rRFs) is modulated in a sex- and population of origin-specific manner. BMC Biol 18, 38 (2020). doi: 10.1186/s12915-020-0763-0. PubMed PMID:32279660.

2016

• Mogilyansky, E, Clark, P, Quann, K, Zhou, H, Londin, E, Jing, Y, Rigoutsos, I. Post-transcriptional Regulation of BRCA2 through Interactions with miR-19a and miR-19b. Front Genet. 2016;7 :143. doi: 10.3389/fgene.2016.00143. PubMed PMID:27630665 PubMed Central PMC5005319.
• Zhou, H, Telonis, AG, Jing, Y, Xia, NL, Biederman, L, Jimbo, M, Blanco, F, Londin, E, Brody, JR, Rigoutsos, I. GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR. Cell Death Dis. 2016;7 :e2294. doi: 10.1038/cddis.2016.169. PubMed PMID:27415424 PubMed Central PMC4973341.

2015

• Telonis, AG, Loher, P, Jing, Y, Londin, E, Rigoutsos, I. Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity. Nucleic Acids Res. 2015;43 (19):9158-75. doi: 10.1093/nar/gkv922. PubMed PMID:26400174 PubMed Central PMC4627084.
• Telonis, AG, Loher, P, Honda, S, Jing, Y, Palazzo, J, Kirino, Y, Rigoutsos, I. Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies. Oncotarget. 2015;6 (28):24797-822. doi: 10.18632/oncotarget.4695. PubMed PMID:26325506 PubMed Central PMC4694795.
• Quann, K, Jing, Y, Rigoutsos, I. Post-transcriptional regulation of BRCA1 through its coding sequence by the miR-15/107 group of miRNAs. Front Genet. 2015;6 :242. doi: 10.3389/fgene.2015.00242. PubMed PMID:26257769 PubMed Central PMC4513244.

2013

• Londin, E, Loher, P, Telonis, AG, Quann, K, Clark, P, Jing, Y, Hatzimichael, E, Kirino, Y, Honda, S, Lally, M, Ramratnam, B, Comstock, CE, Knudsen, KE, Gomella, L, Spaeth, GL, Hark, L, Katz, LJ, Witkiewicz, A, Rostami, A, Jimenez, SA, Hollingsworth, MA, Yeh, JJ, Shaw, CA, McKenzie, SE, Bray, P, Nelson, PT, Zupo, S, Van Roosbroeck, K, Keating, MJ, Calin, GA, Yeo, C, Jimbo, M, Cozzitorto, J, Brody, JR, Delgrosso, K, Mattick, JS, Fortina, P, Rigoutsos, I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc. Natl. Acad. Sci. U.S.A. 2015;112 (10):E1106-15. doi: 10.1073/pnas.1420955112. PubMed PMID:25713380 PubMed Central PMC4364231.
• Fedan, JS, Thompson, JA, Ismailoglu, UB, Jing, Y. Tracheal epithelium cell volume responses to hyperosmolar, isosmolar and hypoosmolar solutions: relation to epithelium-derived relaxing factor (EpDRF) effects. Front Physiol. 2013;4 :287. doi: 10.3389/fphys.2013.00287. PubMed PMID:24130533 PubMed Central PMC3795350.
• He, J, Jing, Y, Li, W, Qian, X, Xu, Q, Li, FS, Liu, LZ, Jiang, BH, Jiang, Y. Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis. PLoS ONE. 2013;8 (2):e56647. doi: 10.1371/journal.pone.0056647. PubMed PMID:23437196 PubMed Central PMC3577861.
• Bray, PF, McKenzie, SE, Edelstein, LC, Nagalla, S, Delgrosso, K, Ertel, A, Kupper, J, Jing, Y, Londin, E, Loher, P, Chen, HW, Fortina, P, Rigoutsos, I. The complex transcriptional landscape of the anucleate human platelet. BMC Genomics. 2013;14 :1. doi: 10.1186/1471-2164-14-1. PubMed PMID:23323973 PubMed Central PMC3722126.

2012

• He, J, Xu, Q, Jing, Y, Agani, F, Qian, X, Carpenter, R, Li, Q, Wang, XR, Peiper, SS, Lu, Z, Liu, LZ, Jiang, BH. Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation. EMBO Rep. 2012;13 (12):1116-22. doi: 10.1038/embor.2012.162. PubMed PMID:23146892 PubMed Central PMC3512405.
• Xu, Q, Jiang, Y, Yin, Y, Li, Q, He, J, Jing, Y, Qi, YT, Xu, Q, Li, W, Lu, B, Peiper, SS, Jiang, BH, Liu, LZ. A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. J Mol Cell Biol. 2013;5 (1):3-13. doi: 10.1093/jmcb/mjs049. PubMed PMID:22935141 PubMed Central PMC3570052.
• Jing, Y, Liu, LZ, Jiang, Y, Zhu, Y, Guo, NL, Barnett, J, Rojanasakul, Y, Agani, F, Jiang, BH. Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells. Toxicol. Sci. 2012;125 (1):10-9. doi: 10.1093/toxsci/kfr256. PubMed PMID:21984483 PubMed Central PMC3243743.

2008

• Jing, Y, Dowdy, JA, Van Scott, MR, Fedan, JS. Simultaneous measurement of mechanical responses and transepithelial potential difference and resistance, in guinea-pig isolated, perfused trachea using a novel apparatus: pharmacological characterization. Eur. J. Pharmacol. 2008;598 (1-3):98-103. doi: 10.1016/j.ejphar.2008.09.009. PubMed PMID:18835555.
• Jing, Y, Dowdy, JA, Van Scott, MR, Fedan, JS. Hyperosmolarity-induced dilation and epithelial bioelectric responses of guinea pig trachea in vitro: role of kinase signaling. J. Pharmacol. Exp. Ther. 2008;326 (1):186-95. doi: 10.1124/jpet.107.135871. PubMed PMID:18413857.

2001

• Gu, Y, Jing, Y, Kumar, A, Sharma, Y, Fujioka, H, Singh, N. Isolation of human neuronal cells resistant to toxicity by the prion protein peptide 106-126. J. Alzheimers Dis. 2001;3 (2):169-180. PubMed PMID:12214058.

1999

• Zanusso, G, Petersen, RB, Jin, T, Jing, Y, Kanoush, R, Ferrari, S, Gambetti, P, Singh, N. Proteasomal degradation and N-terminal protease resistance of the codon 145 mutant prion protein. J. Biol. Chem. 1999;274 (33):23396-404. PubMed PMID:10438517.

• Yi Jing. Epithelial Mechanisms in Airway Responses Induced by Hyperosmolarity: Application of a novel apparatus in understanding the mechanisms of exercise-induced asthma. VDM Verlag, Saarbrücken, Germany, 2009. ISBN-10: 3639198689

Email: Yi.Jing@jefferson.edu