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Home Articles posted by Aristeidis Telonis

Repetitive elements and pyknons in the genes of early development

Genes with highest expression at the blastocyst stage are short and dense in Alu elements Genes involved in pluripotency/proliferation have the opposite structure (length, exon count, Alu density and pyknons) than tissue-specific ones. Genes and…

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Research Papers

miRNAs and tRNA Fragments in Race Disparities in Triple Negative Breast Cancer

Graphic Highlighting Race Disparities as shown by miRNA and tRNA Regulation in Triple Negative Breast Cancer Our study sheds light on how the miRNA isoforms and tRNA fragments re-wire the transcriptome differently in White and Black/African-American…

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Research Papers

N-BLR: a pyknon-containing, primate-specific long non-coding RNA

The pyknon-containing N-BLR is a novel modulator of the epithelial-to-mesenchymal-transition process and of the apoptotic pathway in colorectal cancer We…

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Research Papers

Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types

Graphic Showing Machine Learning Classification Results for Binarized isomiR Profiles on TCGA Datasets We utilized a machine learning approach to predict the cancer type based only on a binary profile of which miRNAs…

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