IsomiR expression profiles in human lymphoblastoid cell lines exhibit population and gender dependencies

Several articles have been published this month on our recent paper, “IsomiR expression profiles in human lymphoblastoid cell lines exhibit population and gender dependencies” by Phillipe Loher, Eric Londin and Isidore Rigoutsos. Click on the links below to read more!

NEW YORK (GenomeWeb) – While recent advances in next-generation sequencing have established the existence of multiple mature microRNA species that arise from the same arm of a hairpin miRNA precursor, new data out of Thomas Jefferson University has revealed a new layer of complexity to this system by showing that these so-called isomiRs can vary depending on gender and population within the same cell type. Read more on genome web.

While microRNAs have been generally thought of as very homogenous little genomic modulators, some new studies are finding that there is actually an entire miRNA cosmos out there with slight variations that are relevant to gender and population differences in mammals. Over at Thomas Jefferson University, Isidore Rigoutsos and his colleagues have already seen some pretty far out mammalian events, including 5′ UTR targeting and individual differences in the miRNA targetome across tissues. Now their molecular observatory has spotted some interesting microRNA isoform dependecies. Read more on epigenie.

Newswise (PHILADELPHIA) – Researchers have encountered variants or isoforms in microRNAs (miRNAs) before, but assumed that these variants were accidental byproducts. A recent study, published in the journal Oncotarget this month, shows that certain so called isomiRs have abundances that depend on geographic subpopulations and gender and that the most prevalent variant of a given miRNA may not be the one typically listed in the public databases. Read more on newswise.

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