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Search Results for: tRNA

In vitro production and multiplex quantification of 2′,3′-cyclic phosphate-containing 5′-tRNA half molecules

Multiplex quantification of 5'-tRNA halves

We synthesized cP-containing 5′-tRNA half molecules and developed a multiplex TaqMan RT-qPCR method which can simultaneously quantify multiple cP-containing 5′-tRNA…

Mitochondrial tRNA-lookalikes in nuclear chromosomes: Could they be functional?

The tRNA-lookalikes for human as well as more information on the identification of tRNA-lookalikes can be found here. If you…

The biogenesis pathway of tRNA-derived piRNAs

Our study revealed the biogenesis pathway of tRNA-derived piRNAs and provided the example of how specific expression profiles of tRNA-derived…

A novel role of tRNA half molecules in immune response as activators of TLR7

A proposed model for 5′-tRNA half-mediated immune response

tRNA half molecules mediate the innate immune response by activating the toll-like receptor TLR7. When a host is infected with…

5′-terminal nucleotide variations in human cytoplasmic tRNAHisGUG and its 5′-halves

We clarified 5′-end variations of human cytoplasmic tRNAHisGUG and its 5′-halves, providing insights into tRNAHisGUG maturation and the regulation of…

5′-tRNA Half Molecules Providing Insights on TLR7 Activation

Toll-like receptor 7 (TLR7) is a vital component of the innate immune system, which also identifies single-stranded RNAs (ssRNAs) as…

MINTmap – tRNA fragment (tRF) mapping tool

MINTmap1 is a program, source code, and lookup table which can be used to generate tRF profiles from short RNA-Seq…

MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects

Interactive graphs of the TCGA tRNA fragments in MINTbase

We expanded MINTbase to include all of The Cancer Genome Atlas datasets (TCGA). They are accompanied by new graphs and…

Mining tRNA-seq data revealed the expression of novel mitochondrial non-coding RNAs

By utilizing YAMAT-seq data, we discovered the expression of novel mitochondrial non-coding RNAs whose expression is regulated by CCA-adding enzyme.…

Expanding the repertoire of tRNA-derived fragments

Distribution of Starting Position and Lengths for i-tRFs for LCL and BRCA Data Sets

Analysis of RNA sequencing data from more than 700 people multiplies the catalogue of tRFs and reveals dependencies on race,…