The roles of GPRC5A in pancreatic ductal adenocarcinoma We found GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from… Continue reading
miRNA isoforms in the breast cancer context Transcending the one-locus-one-miRNA paradigm deepens the understanding of cancer biology and racial health disparities1 MiRNA isoforms (isomiRs) are molecules produced… Continue reading
Expanding the repertoire of tRNA-derived fragments Analysis of RNA sequencing data from more than 700 people multiplies the catalogue of tRFs and reveals dependencies on race,… Continue reading
Non-standard regulation of DNA damage repair by miRNAs The miR-15/107 group of miRNAs regulate BRCA1 expression in a tissue-specific manner through a novel target site in its coding… Continue reading
SHOT-RNAs promote cell growth in cancers We discovered that a novel type of tRNA-derived small RNA, termed SHOT-RNA, is specifically expressed in ER/AR-positive breast and prostate… Continue reading
FL-PCR for quantification of mature tRNAs Four-leaf clover qRT-PCR: A convenient method for selective quantification of mature tRNA1 Transfer RNAs (tRNAs) play a central role in translation… Continue reading
Db-PCR for quantification of RNA variants Dumbbell-PCR: a method to quantify specific small RNA variants with a single nucleotide resolution at terminal sequences Recent advances in… Continue reading
piRNA biogenesis on mitochondria Mitochondrial protein BmPAPI modulates the length of mature piRNAs[1] piRNAs are the 24-31 nucleotides small RNAs that are specifically and… Continue reading
Long RNAs in Human Platelets Analysis of multiple individuals shows extensive differences between the platelet transcriptome and the platelet proteome [1]. The data mentioned in… Continue reading