RNase κ promotes piRNA production by generating 2′,3′-cyclic phosphate (cP-RNA) precursors
In our new publication [1], we show that cP-RNAs serve as piRNA precursors in mouse and silkworm. A mitochondria-associated endoribonuclease,… Research Papers
Summaries of our highlighted papers.
In our new publication [1], we show that cP-RNAs serve as piRNA precursors in mouse and silkworm. A mitochondria-associated endoribonuclease,… In vitro production and multiplex quantification of 2′,3′-cyclic phosphate-containing 5′-tRNA half molecules
We synthesized cP-containing 5′-tRNA half molecules and developed a multiplex TaqMan RT-qPCR method which can simultaneously quantify multiple cP-containing 5′-tRNA… Repetitive elements and pyknons in the genes of early development
Genes involved in pluripotency/proliferation have the opposite structure (length, exon count, Alu density and pyknons) than tissue-specific ones. Genes and… A novel role of tRNA half molecules in immune response as activators of TLR7
tRNA half molecules mediate the innate immune response by activating the toll-like receptor TLR7. When a host is infected with… Oxidative stress enhances the expression of 2′,3′-cyclic phosphate-containing RNAs (cP-RNAs)
By using our original cP-RNA-seq, we have revealed comprehensive expression profiles of 2′,3′-cyclic phosphate-containing RNAs (cP-RNAs) in human cells and… Analysis of rRNA fragments (rRFs) from five human populations reveals dependence on personal attributes
We profiled ribosomal RNA fragments (rRFs) in the RNA-seq datasets from the lymphoblastoid cell lines (LCLs) of the 1000 Genomes… First genome-wide identification of short cyclic phosphate-containing RNAs
Our comprehensive identification of 2′,3′-cyclic phosphate-containing RNAs (cP-RNAs) unraveled a novel, abundant class of non-coding RNAs which may play a… Mining tRNA-seq data revealed the expression of novel mitochondrial non-coding RNAs
By utilizing YAMAT-seq data, we discovered the expression of novel mitochondrial non-coding RNAs whose expression is regulated by CCA-adding enzyme.… Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation
The Computational Medicine Center participated in the Extracellular RNA Communication Consortium (ERCC1), exRNA isolation reproducibility study Over the last few… miRNAs and tRNA Fragments in Race Disparities in Triple Negative Breast Cancer
Our study sheds light on how the miRNA isoforms and tRNA fragments re-wire the transcriptome differently in White and Black/African-American…